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2-MERCAPTOPYRIDINE

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2-MERCAPTOPYRIDINE Basic information

Product Name:
2-MERCAPTOPYRIDINE
Synonyms:
  • MERCAPTO(2-)PYRIDINE
  • 2(1H)-PYRIDINETHIONE
  • 2-Pyridinethiol(7CI,9CI)
  • 2-Mercaptopyridine, 2-Thiopyridine, 2-Sulphanylpyridine
CAS:
73018-10-7
MF:
C5H5NS
MW:
111.16
EINECS:
220-131-9
Product Categories:
  • THIOL
  • 73018-10-7
Mol File:
73018-10-7.mol
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2-MERCAPTOPYRIDINE Chemical Properties

Melting point:
127-130 °C(lit.)
Boiling point:
194℃
Density 
1.166
Flash point:
71℃
storage temp. 
2-8°C
pka
2.22±0.43(Predicted)
CAS DataBase Reference
73018-10-7(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
UT9600000
10-23

MSDS

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2-MERCAPTOPYRIDINE Usage And Synthesis

Uses

Pyridine-2-Thiol (cas# 73018-10-7) is a useful reagent in the preparation of bicalutamide analogues for the potential treatment of prostate cancer.

Definition

ChEBI: Pyridine substituted at C-2 by a sulfanyl group.

Purification Methods

If impure, dissolve in CHCl3, wash with dilute AcOH, H2O, dry (MgSO4), evaporate under reduced pressure and recrystallise the residue from *C6H6 or H2O. 2-Methylmercaptopyridine (b 100-104o/33mm, pK2 0 3.59) was formed by treatment with MeI/NaOH. [Albert & Barlin J Chem Soc 2394 1959, Phillips & Shapiro J Chem Soc 584 1942, Beilstein 21 H 45, 21 III/IV 373, 21/7 V 147.]

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