3-Bromo-6-mercaptopyridine Chemical Properties

Melting point:

202-208°C

Boiling point:

200.9±50.0 °C(Predicted)

Density 

1.79±0.1 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Room Temperature

form 

solid

pka

8.09±0.40(Predicted)

Appearance

Light yellow to yellow Solid

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-37/38-41

Safety Statements 

26-36/37/39

WGK Germany 

3

HS Code 

2933399990

3-Bromo-6-mercaptopyridine Usage And Synthesis

Synthesis

The general procedure for the synthesis of 5-bromo-2-mercaptopyridine from 2-hydroxy-5-bromopyridine was carried out as follows: Lawesson's reagent (2.32 g, 5.74 mmol) was added batchwise to an anhydrous toluene (50 mL) suspension of 5-bromo-2(1H)-pyridone (2 g, 11.5 mmol) and the reaction was carried out under nitrogen protection. The reaction mixture was heated to reflux for 1 h and then cooled to room temperature. The product precipitated during cooling was collected by filtration and dried under high vacuum to afford 5-bromo-2-mercaptopyridine (2.1 g, 96% yield), which could be used in subsequent steps without further purification.

References

[1] Patent: US2012/309796, 2012, A1. Location in patent: Page/Page column 25
[2] Patent: WO2007/39580, 2007, A1. Location in patent: Page/Page column 36
[3] Patent: WO2007/39578, 2007, A1. Location in patent: Page/Page column 42
[4] Patent: WO2007/39581, 2007, A1. Location in patent: Page/Page column 32

3-Bromo-6-mercaptopyridine(56673-34-8)Related Product Information

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• 2-Pyridinethione
• 1-Hexadecylpyridinium bromide
• 2-Ethylhexyl mercaptoacetate
• NICOTINIC ACID HYDRAZIDE
• Calcium thioglycolate
• 3-Mercaptopropionic acid
• 5-BROMO-2-ETHYNYLPYRIDINE
• Pyrimidine, 5-bromo-2-ethyl- (9CI)
• 5-BROMO-PYRIDINE-2-SULFONYL CHLORIDE
• 5-BROMO-2-METHYLSULFANYL-PYRIDINE
• 2-MERCAPTOPYRIDINE
• Bromine
• 2-Mercaptoethanol
• 5-BROMO-2-METHANESULFONYL-PYRIDINE
• 5-BROMO-3-NITRO-PYRIDINE-2-THIOL
• 3-Bromo-6-mercaptopyridine