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Urapidil hydrochloride

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Urapidil hydrochloride Basic information

Product Name:
Urapidil hydrochloride
Synonyms:
  • 6[[3-[4-(O-METHOXYPHENYL)-1-PIPERAZINYL]PROPYL]AMINO]-1,3-DIMETHYLURACIL HYDROCHLORIDE
  • 6-[[3-[4-(2-METHOXYPHENYL)-1-PIPERAZINYL]PROPYL]AMINO]-1,3-DIMETHYL-2,4(1H,3H)-PYRIMIDINEDIONE
  • 6-[[3-[4-(2-METHOXYPHENYL)-1-PIPERAZINYL]PROPYL]AMINO]-1,3-DIMETHYL-2,4(1H,3H)-PYRIMIDINEDIONE HYDROCHLORIDE
  • URAPIDIL HCL
  • URAPIDIL HYDROCHLORIDE
  • URAPIDIL HYDROCHLORIDE A1 ADRENOCEPTOR A NTAG
  • 6-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propylamino]-1,3-dimethyl-pyrimidine-2,4-dione hydrochloride
  • 6-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propylamino]-1,3-dimethylpyrimidine-2,4-dione hydrochloride
CAS:
64887-14-5
MF:
C20H30ClN5O3
MW:
423.94
EINECS:
636-348-0
Product Categories:
  • Adrenoceptor
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
Mol File:
64887-14-5.mol
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Urapidil hydrochloride Chemical Properties

Melting point:
156-1580C
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
H2O: soluble
form 
solid
color 
white
Water Solubility 
Soluble to 50 mM in water
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Safety Information

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
YQ9862000

MSDS

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Urapidil hydrochloride Usage And Synthesis

Description

Urapidil is an antagonist of α1-adrenergic receptors (α1-ARs) and a partial agonist of the serotonin (5-HT) receptor subtype 5-HT1A. It selectively binds to α1- over α2-ARs (IC50s = 0.74 and 42 μM, respectively) and to 5-HT1A over 5-HT1B and 5-HT2 receptors (IC50s = 0.4, 20.4, and >10 μM, respectively) in rat cortex. Urapidil inhibits cAMP accumulation induced by forskolin in calf hippocampus as a functional model for 5-HT1A receptors (EC50 = 390 nM). It is also a β1-AR antagonist that inhibits the positive chronotropic response induced by isoproterenol in isolated rat atria (pA2 = 6.05). Urapidil (1 μmol/kg, i.v.) lowers mean arterial pressure (MAP) in anesthetized cats, an effect that is reduced by central administration of the 5-HT1A receptor antagonist spiroxatrine.

Chemical Properties

White to Off-White Crystalline Powder

Uses

α1-Adrenergic antagonist; derivative of Uracil (U801000). Antihypertensive.

Uses

Antihypertensive;Serotonergic receptor agonist

Uses

a1-Adrenergic antagonist; derivative of Uracil. Antihypertensive

Biological Activity

α 1 -adrenoceptor antagonist and 5-HT 1A receptor agonist (pIC 50 values are 6.13 and 6.4 respectively). Clinically used hypotensive agent.

Urapidil hydrochlorideSupplier

Tianjin Hankang Pharmaceutical Biotechnology Co. Ltd Gold
Tel
22-23256366 15620629054
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ivyding@drughk.com
Sichuan Aupone Pharmaceutical Trading Co. , Ltd. Gold
Tel
028-87843998 18980796919
Email
236656639@qq.com
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Email
jkinfo@jkchemical.com
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Email
3bsc@sina.com
LGM Pharma
Tel
1-(800)-881-8210
Email
inquiries@lgmpharma.com
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Urapidil hydrochloride(64887-14-5)Related Product Information