Basic information Safety Supplier Related
ChemicalBook >  Product Catalog >  API >  Circulatory system drugs >  Angina Pectoris Drugs >  Urapidil hydrochloride

Urapidil hydrochloride

Basic information Safety Supplier Related

Urapidil hydrochloride Basic information

Product Name:
Urapidil hydrochloride
Synonyms:
  • 6[[3-[4-(O-METHOXYPHENYL)-1-PIPERAZINYL]PROPYL]AMINO]-1,3-DIMETHYLURACIL HYDROCHLORIDE
  • 6-[[3-[4-(2-METHOXYPHENYL)-1-PIPERAZINYL]PROPYL]AMINO]-1,3-DIMETHYL-2,4(1H,3H)-PYRIMIDINEDIONE
  • 6-[[3-[4-(2-METHOXYPHENYL)-1-PIPERAZINYL]PROPYL]AMINO]-1,3-DIMETHYL-2,4(1H,3H)-PYRIMIDINEDIONE HYDROCHLORIDE
  • URAPIDIL HCL
  • URAPIDIL HYDROCHLORIDE
  • URAPIDIL HYDROCHLORIDE A1 ADRENOCEPTOR A NTAG
  • 6-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propylamino]-1,3-dimethyl-pyrimidine-2,4-dione hydrochloride
  • 6-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propylamino]-1,3-dimethylpyrimidine-2,4-dione hydrochloride
CAS:
64887-14-5
MF:
C20H30ClN5O3
MW:
423.94
EINECS:
636-348-0
Product Categories:
  • Adrenoceptor
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • 64887-14-5
Mol File:
64887-14-5.mol
More
Less

Urapidil hydrochloride Chemical Properties

Melting point:
156-1580C
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
H2O: soluble
form 
solid
color 
white
Water Solubility 
Soluble to 50 mM in water
InChI
InChI=1S/C20H29N5O3.ClH/c1-22-18(15-19(26)23(2)20(22)27)21-9-6-10-24-11-13-25(14-12-24)16-7-4-5-8-17(16)28-3;/h4-5,7-8,15,21H,6,9-14H2,1-3H3;1H
InChIKey
KTMLZVUAXJERAT-UHFFFAOYSA-N
SMILES
O(C1C=CC=CC=1N1CCN(CCCNC2=CC(=O)N(C)C(=O)N2C)CC1)C.Cl
More
Less

Safety Information

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
YQ9862000

MSDS

More
Less

Urapidil hydrochloride Usage And Synthesis

Description

Urapidil is an antagonist of α1-adrenergic receptors (α1-ARs) and a partial agonist of the serotonin (5-HT) receptor subtype 5-HT1A. It selectively binds to α1- over α2-ARs (IC50s = 0.74 and 42 μM, respectively) and to 5-HT1A over 5-HT1B and 5-HT2 receptors (IC50s = 0.4, 20.4, and >10 μM, respectively) in rat cortex. Urapidil inhibits cAMP accumulation induced by forskolin in calf hippocampus as a functional model for 5-HT1A receptors (EC50 = 390 nM). It is also a β1-AR antagonist that inhibits the positive chronotropic response induced by isoproterenol in isolated rat atria (pA2 = 6.05). Urapidil (1 μmol/kg, i.v.) lowers mean arterial pressure (MAP) in anesthetized cats, an effect that is reduced by central administration of the 5-HT1A receptor antagonist spiroxatrine.

Chemical Properties

White to Off-White Crystalline Powder

Uses

α1-Adrenergic antagonist; derivative of Uracil (U801000). Antihypertensive.

Uses

Antihypertensive;Serotonergic receptor agonist

Uses

a1-Adrenergic antagonist; derivative of Uracil. Antihypertensive

Biological Activity

α 1 -adrenoceptor antagonist and 5-HT 1A receptor agonist (pIC 50 values are 6.13 and 6.4 respectively). Clinically used hypotensive agent.

Side effects

Side effects that may occur during treatment with uradil antihypertension include dizziness, fatigue, nausea, and light-headedness effects. The increases in systolic blood pressure heart rate caused by three progressive work loads bicycle exercise were not affected during urapidil, A slight reduction in forced expiratory volume was observed in some patients during treatment with beta-blocker. There was no case orthostatic hypotension during urapidil administration, despite its alpha1-blocking action. Side-effects were rare negligible[1].

References

[1] G LEONETTI. Comparison of the antihypertensive effect of urapidil and metoprolol in hypertension.[J]. European Journal of Clinical Pharmacology, 1986, 30 6: 637-640. DOI:10.1007/BF00608208.

Urapidil hydrochlorideSupplier

Tianjin Hankang Pharmaceutical Biotechnology Co. Ltd Gold
Tel
22-23256366 15620629054
Email
ivyding@drughk.com
Chengdu Aupone Pharmaceutical Co.,Ltd. Gold
Tel
18980796919
Email
236656639@qq.com
Pushan Industry (Shaanxi) Co., Ltd. Gold
Tel
029-81310890 13571859809
Email
info@pushanshiye.com
Wuhan ze shan cheng Biomedical Technology Co., Ltd. Gold
Tel
027-51477051 17786425391
Email
jim@zeshancheng.com
Hunan Tengyu New Materials Co., Ltd. Gold
Tel
1822-9738810 18229738810
Email
3590064534@qq.com