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3-Hydroxy-N-methyl-3-phenyl-propylamine

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3-Hydroxy-N-methyl-3-phenyl-propylamine Basic information

Product Name:
3-Hydroxy-N-methyl-3-phenyl-propylamine
Synonyms:
  • ALPHA-(2-METHYLAMINO)-ETHYLBENZENEMETHANOL
  • ALPHA-[2-(METHYLAMINO)ETHYL]BENZYL ALCOHOL
  • 3-HYDROXY-N-METHYL-3-PHENYLPROPYLAMINE
  • 3-METHYLAMINO-1-PHENYLPROPANOL
  • 3-(METHYLAMINO)-1-PHENYLPROPAN-1-OL
  • 3-METHYLAMINO-1-PHENYL-1-PROPANOL
  • N-METHYL-3-PHENYL-3-HYDROXYPROPYLAMINE
  • N-METHYL-3-HYDROXY-3-PHENYL PROPYLAMINE
CAS:
42142-52-9
MF:
C10H15NO
MW:
165.24
EINECS:
255-679-8
Product Categories:
  • Amino Alcohols
  • Building Blocks
  • Intermediates of Fluoxetine
  • Chemical Synthesis
  • Organic Building Blocks
  • Oxygen Compounds
  • INTERMEDIATESOFFLUOXETINE
  • Amino Alcohols
  • Organic Building Blocks
  • Oxygen Compounds
Mol File:
42142-52-9.mol
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3-Hydroxy-N-methyl-3-phenyl-propylamine Chemical Properties

Melting point:
64 °C
Boiling point:
170 °C / 31mmHg
Density 
1.017±0.06 g/cm3(Predicted)
vapor pressure 
0.037Pa at 25℃
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
DMSO (Soluble), Methanol (Slightly)
pka
14.24±0.20(Predicted)
form 
Solid
color 
Off-White to Pale Yellow
InChI
InChI=1S/C10H15NO/c1-11-8-7-10(12)9-5-3-2-4-6-9/h2-6,10-12H,7-8H2,1H3
InChIKey
XXSDCGNHLFVSET-UHFFFAOYSA-N
SMILES
C(C1C=CC=CC=1)(O)CCNC
LogP
0.98
CAS DataBase Reference
42142-52-9(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
36/37
WGK Germany 
3
HS Code 
2922199695

MSDS

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3-Hydroxy-N-methyl-3-phenyl-propylamine Usage And Synthesis

Chemical Properties

Off-White Solid

Uses

α-[2-(Methylamino)ethyl]benzyl Alcohol (Fluoxetine EP Impurity A(Atomoxetine Related Compound A)) is an aromatic amino alcohol used as an initiator in radical addition reactions with tetrahalomethanes.This compound is found as an impurity in fluoxetine (F597100).

Uses

3-Hydroxy-N-methyl-3-phenyl-propylamine is an aromatic amino alcohol used as an initiator in radical addition reactions with tetrahalomethanes.

Synthesis

3-Hydroxy-N-methyl-3-phenyl-propylamine is one of important intermediate of preparation fluoxetine Hydrochloride. Up to now, the method for preparing N-methyl-3-phenyl-3-hydroxy-propylamine is mainly divided into three kinds; the first kind of be replace (halogen with 3-, dialkylamine, amido or ethoxycarbonyl) Propiophenone be starting raw material, earlier after reduction, the 1-phenylpropyl alcohol that 3-is replaced is converted into 3-Hydroxy-N-methyl-3-phenyl-propylamine again; Second kind and being: the different azoles alkane of 2-methyl-5-phenyl is carried out reductive ring open makes target compound; The third be: with getting the 1-phenylpropyl alcohol that 3-replaces behind epoxy styrene and the derivative reductive ring open thereof, be translated into target compound earlier.

3-Hydroxy-N-methyl-3-phenyl-propylamine Preparation Products And Raw materials

Preparation Products

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