3-Hydroxy-N-methyl-3-phenyl-propylamine Chemical Properties

Melting point:

64 °C

Boiling point:

170 °C / 31mmHg

Density 

1.017±0.06 g/cm3(Predicted)

vapor pressure 

0.037Pa at 25℃

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

DMSO (Soluble), Methanol (Slightly)

pka

14.24±0.20(Predicted)

form 

Solid

color 

Off-White to Pale Yellow

InChI

InChI=1S/C10H15NO/c1-11-8-7-10(12)9-5-3-2-4-6-9/h2-6,10-12H,7-8H2,1H3

InChIKey

XXSDCGNHLFVSET-UHFFFAOYSA-N

SMILES

C(C1C=CC=CC=1)(O)CCNC

LogP

0.98

CAS DataBase Reference

42142-52-9(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

Safety Statements 

36/37

WGK Germany 

3

HS Code 

2922199695

MSDS

• Language:English Provider:3-Hydroxy-N-methyl-3-phenyl-propylamine

3-Hydroxy-N-methyl-3-phenyl-propylamine Usage And Synthesis

Chemical Properties

Off-White Solid

Uses

α-[2-(Methylamino)ethyl]benzyl Alcohol (Fluoxetine EP Impurity A(Atomoxetine Related Compound A)) is an aromatic amino alcohol used as an initiator in radical addition reactions with tetrahalomethanes.This compound is found as an impurity in fluoxetine (F597100).

Uses

3-Hydroxy-N-methyl-3-phenyl-propylamine is an aromatic amino alcohol used as an initiator in radical addition reactions with tetrahalomethanes.

Synthesis

3-Hydroxy-N-methyl-3-phenyl-propylamine is one of important intermediate of preparation fluoxetine Hydrochloride. Up to now, the method for preparing N-methyl-3-phenyl-3-hydroxy-propylamine is mainly divided into three kinds; the first kind of be replace (halogen with 3-, dialkylamine, amido or ethoxycarbonyl) Propiophenone be starting raw material, earlier after reduction, the 1-phenylpropyl alcohol that 3-is replaced is converted into 3-Hydroxy-N-methyl-3-phenyl-propylamine again; Second kind and being: the different azoles alkane of 2-methyl-5-phenyl is carried out reductive ring open makes target compound; The third be: with getting the 1-phenylpropyl alcohol that 3-replaces behind epoxy styrene and the derivative reductive ring open thereof, be translated into target compound earlier.

References

[1] Patent: CN103992236, 2016, B. Location in patent: Paragraph 0051;0054; 0055
[2] Angewandte Chemie - International Edition, 2005, vol. 44, # 11, p. 1687 - 1689

3-Hydroxy-N-methyl-3-phenyl-propylamine(42142-52-9)Related Product Information

• Benzyl benzoate
• Methyl acrylate
• Ethyl acetate
• Trimethylamine
• Benzyl bromide
• 1-Propanol
• Ethanol
• PHENYL VALERATE
• Ethylparaben
• Benzhydrylamine
• CHLOROPHOSPHONAZO III
• Benzyl alcohol
• Methylparaben
• trimethylamine oxide
• 1-Phenyl-1-propanol
• Kresoxim-methyl
• 3-Phenyl-1-propanol
• Flunixin meglumine