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H-GLY-TYR-PRO-GLY-GLN-VAL-OH

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H-GLY-TYR-PRO-GLY-GLN-VAL-OH Basic information

Product Name:
H-GLY-TYR-PRO-GLY-GLN-VAL-OH
Synonyms:
  • GLY-TYR-PRO-GLY-GLN-VAL
  • H-GLY-TYR-PRO-GLY-GLN-VAL-OH
  • PROTEINASE ACTIVATED RECEPTOR 4 AGONIST PEPTIDE (GYPGQV), HUMAN
  • PAR-4 AGONIST PEPTIDE (GYPGQV), HUMAN
  • PAR-4 (1-6) (HUMAN)
  • PAR 4 (1-6)
  • GYPGQV, Coagulation Factor II Receptor-Like 3 (1-6) (huMan), Proteinase Activated Receptor 4 (1-6) (huMan), ThroMbin Receptor-Like 3 (1-6) (huMan)
  • Glycyl-L-tyrosyl-L-prolyl-glycyl-L-glutaminyl-L-valine trifluoroacetate salt
CAS:
225779-44-2
MF:
C28H41N7O9
MW:
619.67
Mol File:
225779-44-2.mol
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H-GLY-TYR-PRO-GLY-GLN-VAL-OH Chemical Properties

storage temp. 
-15°C
solubility 
H2O: >2mg/mL
form 
powder
color 
white to tan
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Safety Information

WGK Germany 
3
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H-GLY-TYR-PRO-GLY-GLN-VAL-OH Usage And Synthesis

Description

PAR4 (1-6) is a peptide agonist of proteinase-activated receptor 4 (PAR4) that corresponds to residues 1-6 of the amino terminal tethered ligand sequence of human PAR4 and residues 48-53 of the full-length sequence. It activates PAR4 and the cleavage site mutant PAR4R47A when used at a concentration of 500 μM. PAR4 (1-6) induces platelet aggregation of isolated washed human platelets when used at a concentration of 1 mM but does not affect clotting time induced by factor VIIa, soluble tissue factor, and collagen in an ex vivo coagulation assay.

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