2-Methyl-5-nitrobenzaldehyde Chemical Properties

Melting point:

53.0 to 57.0 °C

Boiling point:

114°C/0.2mmHg(lit.)

Density 

1.278±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

form 

powder to crystal

color 

White to Light yellow to Light orange

Safety Information

HS Code 

2913000090

2-Methyl-5-nitrobenzaldehyde Usage And Synthesis

Synthesis

General steps: 1. In a dry reaction flask, 2-methyl-5-nitrobenzyl alcohol (20 mmol) was dissolved in dichloromethane (DCM, 100 mL). 2. Pyridinium chlorochromate (PCC, 28-40 mmol) was added to the above solution. 3. The reaction mixture was heated to reflux (oil bath temperature was maintained at 55 °C) and the reaction lasted for 1-4 hours. 4. The progress of the reaction was monitored by thin layer chromatography (TLC) and/or liquid chromatography-mass spectrometry (LCMS) during the reaction. 5. Upon completion of the reaction, the mixture was cooled to room temperature. 6. post-processing, including isolation and purification of the product, is carried out according to the method described in variant B.

References

[1] Patent: US2015/218086, 2015, A1. Location in patent: Paragraph 0529; 0530; 0573
[2] Patent: WO2017/24009, 2017, A1. Location in patent: Paragraph 0560; 0592

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