Butanilicaine hydrochloride Chemical Properties

Melting point:

45-46°

Boiling point:

bp0.001 145°; bp0.5 166-167°

Density 

1.129±0.06 g/cm3(Predicted)

storage temp. 

Refrigerator

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Solid

pka

13.41±0.70(Predicted)

color 

Pale Brown to Light Brown

NIST Chemistry Reference

Butanilicaine(3785-21-5)

Butanilicaine hydrochloride Usage And Synthesis

Originator

Butanilicaine,Enreco, INC

Uses

Butanilicaine Hydrochloride, is a local anesthetic.

Definition

ChEBI: An amino acid amide amide in which N-butylglycine and 2-chloro-6-methylaniline have combined to form the amide bond; used as a local anaesthetic (amide caine).

Manufacturing Process

To a solution of 4-bromo-2-methylaniline is added 13 g of chloroacetyl chloride. After the reaction is finished to the mixture id added a solution of 33 g sodium acetate in 138 ml of water. Chloroacetic acid 4-bromo-2- methylanilide is filtered; yield 24 g, M.P. 135°C (crystallization from ethanol).
20 g of chloroacetic acid 4-bromo-2-methylanilide is dissolved in 200 ml of butylamine. After about 15 hours to the solution is added 2 N hydrochloric acid. Butylaminoacetic acid 4-bromo-2-methylanilide hydrochloride is removed by suction and washed with water; yield 90%, M.P. 252-253°C (from methanol).

Therapeutic Function

Local anesthetic

Butanilicaine hydrochloride(3785-21-5)Related Product Information

• N,N-Dimethyl-1,4-phenylenediamine
• D-Glucosamine hydrochloride
• Topotecan hydrochloride
• Epichlorohydrin
• Tris(hydroxymethyl)aminomethane
• Benzocaine
• Acetamide
• Trimethylphenylammonium chloride
• Dichloromethylphenylsilane
• N,N-Dimethylacetamide
• Articaine
• Mepivacaine hydrochloride
• Aminoacetonitrile hydrochloride
• Chloroacetic acid
• Difluorochloromethane
• 2-CHLORO-6-METHYLACETANILINE
• Butanilicaine hydrochloride
• 1-Pyrrolidineacetamide, N-(2-chloro-6-methylphenyl)-alpha-propyl-, mon ohydrochloride