Etofenamate Chemical Properties

Melting point:

25°C

Boiling point:

bp.001 130-135°

Density 

1.2866 (estimate)

refractive index 

nD25 1.564

storage temp. 

Sealed in dry,2-8°C

solubility 

Practically insoluble in water, miscible with ethanol (96 per cent) and with ethyl acetate.

pka

14.32±0.10(Predicted)

Stability:

Light Sensitive

Safety Information

RIDADR 

UN2810 - class 6.1 - PG 3 - EHS - Toxic, liquids, organic, n.o.s., HI: all

Toxicity

LD50 in male, female rats (mg/kg): 292, 470 orally; 140, 226 i.v.; 373, 397 i.p.; 643, 568 s.c. (Jacobi)

Etofenamate Usage And Synthesis

Chemical Properties

Light Yellow Oil

Originator

Rheumon,Troponwerke,W. Germany,1977

Uses

As a histamine H1 -receptor antagonist, Etofenamate can be used as anti-inflammatory;cyclooxygenase inhibitor and medication used to alleviate joint and muscle pain.

Definition

ChEBI: 2-[3-(trifluoromethyl)anilino]benzoic acid 2-(2-hydroxyethoxy)ethyl ester is a benzoate ester.

Manufacturing Process

16.0 g (0.05 mol) of the potassium salt of N-(3-trifluoromethylphenyl)- anthranilic acid are dissolved in 60 ml of dimethylformamide and heated to 110°C, and 6.2 g (0.05 mol) of 2-(2-chloroethoxy)-ethanol are slowly added. The reaction mixture is then heated to boiling for 2 hours. The precipitated potassium chloride is filtered off and the solvent is removed by evaporation. The residue is separated over a column with 400 g of silica gel (particle size 0.05 to 0.2 mm), using a 1:1 mixture of cyclohexane and glacial acetic acid as eluting agent. 16.0 g of the 2-(2-hydroxyethoxy)-ethyl ester of N-(3- trifluoromethylphenyl)-anthranilic acid are obtained in the form of a pale yellow oil which does not crystallize and cannot be distilled.

Therapeutic Function

Antiinflammatory

Etofenamate(30544-47-9)Related Product Information

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