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Etofenamate

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Etofenamate Basic information

Product Name:
Etofenamate
Synonyms:
  • EtofenamateEtofenamate
  • 2-(2-hydroxyaethoxy)aethylester der flutenaminsaeure
  • 2-(2-hydroxyethoxy)ethyl-n-(alpha,alpha,alpha-trifluoro-m-tolyl)anthrani late
  • Benzoic acid, 2[[3-(trifluoromethyl)phenyl]amino]-2-(hydroxyethoxy)ethyl ester
  • n-(alpha,alpha,alpha-trifluoro-m-tolyl)-anthranilic acid 2-(2-hydroxyethoxy)
  • 2-(2-Hydroxyethoxy)ethyl 2-[3-(trifluoromethyl)anilino]benzoate
  • Ethofenamate
  • Rheumon
CAS:
30544-47-9
MF:
C18H18F3NO4
MW:
369.33
EINECS:
250-231-8
Product Categories:
  • Inhibitors
  • Amines
  • Aromatics
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
Mol File:
30544-47-9.mol
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Etofenamate Chemical Properties

Melting point:
25°C
Boiling point:
bp.001 130-135°
Density 
1.2866 (estimate)
refractive index 
nD25 1.564
storage temp. 
Sealed in dry,2-8°C
solubility 
Practically insoluble in water, miscible with ethanol (96 per cent) and with ethyl acetate.
pka
14.32±0.10(Predicted)
form 
Oil
color 
Light yellow to yellow
Stability:
Light Sensitive
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Safety Information

RIDADR 
UN2810 - class 6.1 - PG 3 - EHS - Toxic, liquids, organic, n.o.s., HI: all
Toxicity
LD50 in male, female rats (mg/kg): 292, 470 orally; 140, 226 i.v.; 373, 397 i.p.; 643, 568 s.c. (Jacobi)
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Etofenamate Usage And Synthesis

Chemical Properties

Light Yellow Oil

Originator

Rheumon,Troponwerke,W. Germany,1977

Uses

As a histamine H1 -receptor antagonist, Etofenamate can be used as anti-inflammatory;cyclooxygenase inhibitor and medication used to alleviate joint and muscle pain.

Definition

ChEBI: 2-[3-(trifluoromethyl)anilino]benzoic acid 2-(2-hydroxyethoxy)ethyl ester is a benzoate ester.

Manufacturing Process

16.0 g (0.05 mol) of the potassium salt of N-(3-trifluoromethylphenyl)- anthranilic acid are dissolved in 60 ml of dimethylformamide and heated to 110°C, and 6.2 g (0.05 mol) of 2-(2-chloroethoxy)-ethanol are slowly added. The reaction mixture is then heated to boiling for 2 hours. The precipitated potassium chloride is filtered off and the solvent is removed by evaporation. The residue is separated over a column with 400 g of silica gel (particle size 0.05 to 0.2 mm), using a 1:1 mixture of cyclohexane and glacial acetic acid as eluting agent. 16.0 g of the 2-(2-hydroxyethoxy)-ethyl ester of N-(3- trifluoromethylphenyl)-anthranilic acid are obtained in the form of a pale yellow oil which does not crystallize and cannot be distilled.

Therapeutic Function

Antiinflammatory

EtofenamateSupplier

Shaoxing Hongda Medical Technology Co.,Ltd Gold
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Shanghai Boyle Chemical Co., Ltd.
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J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788
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Adamas Reagent, Ltd.
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Chemsky(shanghai)International Co.,Ltd.
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021-50135380
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