6-Chloro-2,3-diaminopyridine Chemical Properties

Melting point:

132.0 to 136.0 °C

Boiling point:

360.2±37.0 °C(Predicted)

Density 

1.447±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

pka

2.69±0.50(Predicted)

form 

powder to crystal

color 

White to Brown to Dark purple

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-36/37/38-42/43-33-23/24/25

Safety Statements 

22-36/37-45-37-28

RIDADR 

2811

WGK Germany 

3

HazardClass 

6.1

HS Code 

29333990

6-Chloro-2,3-diaminopyridine Usage And Synthesis

Application

6-Chloro-2,3-diaminopyridine is an organic synthesis intermediate and a pharmaceutical intermediate that can be used in laboratory research and development processes as well as in chemical and pharmaceutical synthesis.

Chemical Properties

Dark green solid

Synthesis

6-Chloro-2-nitropyridin-3-amine (E-23) (8.8 g, 51 mmol, 1.0 eq.) was used as a raw material and mixed with Ruanne nickel (0.88 g) in methanol (100 mL). The reaction mixture was stirred at room temperature for 24 hours under hydrogen atmosphere. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated under vacuum to afford the target product 6-chloropyridine-2,3-diamine (E-24) (7 g, 95.6% yield) as a pale white solid. The product was detected by ESI-MS, m/z: 144.05 [M + H]+.

References

[1] Patent: WO2011/149937, 2011, A1. Location in patent: Page/Page column 40; 41; 84
[2] Patent: WO2013/78441, 2013, A1. Location in patent: Paragraph 00143; 00326
[3] Patent: WO2014/151147, 2014, A1. Location in patent: Paragraph 00641
[4] Patent: US2015/30588, 2015, A1. Location in patent: Page/Page column 66
[5] Patent: US9295673, 2016, B2. Location in patent: Page/Page column 341; 342

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