3-BROMO-2-CHLORO-5-NITRO-6-PICOLINE Chemical Properties

Melting point:

93℃

Boiling point:

296℃

Density 

1.810

Flash point:

133℃

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

form 

solid

pka

-4.03±0.10(Predicted)

Appearance

Off-white to light yellow Solid

InChI

InChI=1S/C6H4BrClN2O2/c1-3-5(10(11)12)2-4(7)6(8)9-3/h2H,1H3

InChIKey

WKGHUAZJNBXABN-UHFFFAOYSA-N

SMILES

C1(Cl)=NC(C)=C([N+]([O-])=O)C=C1Br

Safety Information

HS Code 

2933399990

3-BROMO-2-CHLORO-5-NITRO-6-PICOLINE Usage And Synthesis

Chemical Properties

light yellow crystal powder

Synthesis

3-Bromo-6-methyl-5-nitropyridin-2-ol (9.2 g, 36.7 mmol) was used as starting material, which was dissolved in phosphorus oxychloride (POCl3, 56.2 g, 366.7 mmol). The reaction mixture was stirred and reacted at 80 °C overnight. Upon completion of the reaction, the mixture was slowly poured into water (800 mL) and the solid product was precipitated. The solid was collected by filtration and dried to afford the target compound 3-bromo-2-chloro-5-nitro-6-methylpyridine (7.5 g, 81.4% yield).

References

[1] Patent: US2018/170909, 2018, A1. Location in patent: Paragraph 1925; 1926
[2] Patent: WO2015/89192, 2015, A1. Location in patent: Paragraph 00275; 00276
[3] Patent: WO2016/37005, 2016, A1. Location in patent: Paragraph 00259-00260
[4] Patent: WO2008/101682, 2008, A2. Location in patent: Page/Page column 42-43

3-BROMO-2-CHLORO-5-NITRO-6-PICOLINE(856834-95-2)Related Product Information

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