FLUOROACETAMIDE Chemical Properties

Melting point:

106-108 °C(lit.)

Boiling point:

259.0±10.0 °C(Predicted)

Density 

1.1170 (estimate)

solubility 

DMSO (Soluble), Methanol (Slightly)

form 

Solid

pka

14.60±0.40(Predicted)

color 

Off-White to Pale Beige

Merck 

13,4193

BRN 

1739054

Stability:

Stable.

CAS DataBase Reference

640-19-7(CAS DataBase Reference)

EPA Substance Registry System

Fluoroacetamide (640-19-7)

Safety Information

Hazard Codes 

T+,T,Xi

Risk Statements 

24-28

Safety Statements 

36/37-45

RIDADR 

UN 2811 6.1/PG 2

WGK Germany 

2

RTECS 

AC1225000

Hazard Note 

Highly Toxic/Irritant

HazardClass 

6.1(a)

PackingGroup 

I

HS Code 

29241200

Hazardous Substances Data

640-19-7(Hazardous Substances Data)

Toxicity

LD50 i.p. in mice: 85 mg/kg (Matsumura, O'Brien)

MSDS

• Language:English Provider:SigmaAldrich

FLUOROACETAMIDE Usage And Synthesis

Description

Fluoroacetamide is an odourless, tasteless, white, crystalline water soluble. It is a fluorinated amide and reacts with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Fluoroacetamide is used as a rodenticide and insecticide to control rabbits but is dangerous for other species of pests, farm livestock, and humans. Fluoroacetamide is a noncombustible substance itself and does not burn but may decompose upon heating to produce irritating, corrosive, and/or toxic fumes. On decomposition, fluoroacetamide releases nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, HF gas, and nitrogen gas.

Chemical Properties

crystals

Chemical Properties

Fluoroacetamide is a colorless, crystalline solid.

Uses

Rodenticide. Insecticide proposed mainly for use on fruits to combat scale insects, aphids, and mites.

Production Methods

Fluoroacetamide is produced by reaction of α-chloroacetamide with potassium fluoride in tetrachloroethylene at elevated temperature.

Definition

ChEBI: Acetamide substituted at C-2 by a fluorine atom.

General Description

Colorless crystalline powder. Used as a rodenticide. Highly toxic.

Air & Water Reactions

Very soluble in water [Farm Chemicals]

Reactivity Profile

FLUOROACETAMIDE is a fluorinated amide. Organic amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).

Hazard

Extremely toxic; poison; mutagen.

Health Hazard

FLUOROACETAMIDE is super toxic; probable oral lethal dose in humans is less than 5 mg/kg, or a taste (less than 7 drops) for a 150-lb. person. Chemically inhibits oxygen metabolism by cells with critical damage occurring to the heart, brain, and lungs resulting in heart failure, respiratory arrest, convulsions, and death.

Fire Hazard

Emits very toxic fumes of fluorine containing compounds and nitrogen oxides when heated to decomposition. Avoid decomposing heat.

Safety Profile

A human poison by an unspecified route. Poison experimentally by ingestion, skin contact, intraperitoneal, subcutaneous, and intravenous routes. Human systemic effects by unspecified route: convulsions, coma, nausea and vomiting. Experimental reproductive effects. Mutation data reported. Used as an insecticide and rodenticide. When heated to decomposition it emits very toxic fumes of Fand NOx. See also FLUORIDES.

Potential Exposure

This material is an organofluorine rodenticide; insecticide proposed mainly for use on fruits to combat scale insects, aphids, and mites. Use is largely restricted to licensed pest control operators.

storage

Color Code—Blue: Health Hazard/Poison: Storein a secure poison location. Prior to working with thischemical you should be trained on its proper handling andstorage. Store in tightly closed containers in a cool, wellventilated area.

Shipping

UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

Purification Methods

Crystallise fluoroacetamide from chloroform and dry it in a vacuum. [Beilstein 2 IV 454.]

Incompatibilities

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explo sions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.

Waste Disposal

Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations govern ing storage, transportation, treatment, and waste disposal.

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