Basic information Uses Safety Supplier Related

dihydrolycorine

Basic information Uses Safety Supplier Related

dihydrolycorine Basic information

Product Name:
dihydrolycorine
Synonyms:
  • (1S,2S,3aR,12bS,12cR)-2,3,3a,4,5,7,12b,12c-Octahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol
  • 1H-[1,3]Dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol, 2,3,3a,4,5,7,12b,12c-octahydro-, (1S,2S,3aR,12bS,12cR)-
  • Dihydrolycorine,inhibit,Inhibitor
CAS:
6271-21-2
MF:
C16H19NO4
MW:
289.33
Mol File:
6271-21-2.mol
More
Less

dihydrolycorine Chemical Properties

Melting point:
247 °C
Boiling point:
460.5±45.0 °C(Predicted)
Density 
1.48
solubility 
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form 
Cryst.
pka
14.13±0.40(Predicted)
More
Less

dihydrolycorine Usage And Synthesis

Uses

Dihydrolycorine is a derivative of Lycorine, the main phenanthridine Amaryllidaceae alkaloid which exhibits significant antitumor activity in cancer cells that display resistance to proapoptotic stimuli.

Description

Dihydrolycorine is a derivative of the alkaloid lycorine that has antihypertensive and neuroprotective activities. It inhibits methoxamine-induced contraction of isolated rabbit aortic rings and rat anococcygeus muscle with pA2 values of 5.93 and 6.35, respectively. Dihydrolycorine reduces mean arterial pressure (MAP) in anesthetized and conscious normotensive rats when administered at a dose of 80 mg/kg. It also reduces electrically or phenylephrine-induced hypertension in pithed rats. Dihydrolycorine reduces infarct size, cerebral edema, and myeloperoxidase activity in a rat model of focal cerebral ischemia-reperfusion injury when administered following reperfusion.

Uses

Dihydrolycorine is a derivative of Lycorine (L487550), the main phenanthridine Amaryllidaceae alkaloid which exhibits significant antitumor activity in cancer cells that display resistance to proapoptotic stimuli.

target

Adrenergic Receptor

dihydrolycorineSupplier

ChengDu YiRui Bio-Technology CO., LTD Gold
Tel
17345243906 18224028459
Email
tangcongxin2020@163.com
Chembest Research Laboratories Limited
Tel
021-20908456
Email
sales@BioChemBest.com
Chengdu Climax Biotech Co., Ltd.
Tel
028-83311324 1278112614
Email
climaxbiotech@gmail.com
Hangzhou Sage Chemical Co., Ltd.
Tel
+86057186818502 13588463833
Email
info@sagechem.com
Shanghai Tauto Biotech Co., Ltd.
Tel
021-51320588
Email
tauto@tautobiotech.com