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MOMORDINIC

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MOMORDINIC Basic information

Product Name:
MOMORDINIC
Synonyms:
  • MorModin Ic
  • MOMORDINIC
  • 28-norolean-12-en-3-yl 3-O-β-D-xylopyranosyl-
  • β-D-Glucopyranosiduronic acid, (3β)-17-carboxy-
  • Momordin IC, 98%, from Kochia scoparia(L.)Schrad.
  • Momordin 1c
  • Ic Momordin Ic
  • 28-Noroleanane,β-D-glucopyranosiduronic acid deriv
CAS:
96990-18-0
MF:
C41H64O13
MW:
764.94
Product Categories:
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • chemical reagent
Mol File:
96990-18-0.mol
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MOMORDINIC Chemical Properties

Melting point:
238-240 °C
Boiling point:
886.2±65.0 °C(Predicted)
Density 
1.35±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Methanol (Slightly, Heated, Sonicated), Pyridine (Slightly)
form 
Solid
pka
2.75±0.70(Predicted)
color 
White to Pale Yellow
optical activity
[α]/D 12 to 17° in methanol (c=0.5 g/100mL)
Stability:
Hygroscopic
InChIKey
HWYBGIDROCYPOE-UAEHAXNUNA-N
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Safety Information

Safety Statements 
24/25
HS Code 
29389090
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MOMORDINIC Usage And Synthesis

Chemical Properties

Light yellow crystalline powder, soluble in methanol, derived from Kochia scoparia seeds.

Uses

Mormodin Ic is used as an anti-cancer agent, and is shown to induce HepG2 apoptosis in a PI3K and MAPK pathway-dependant manner.

Definition

ChEBI: Momordin ic is a triterpenoid saponin.

Biological Activity

Potent inhibitor of SUMO-specific protease 1 (SENP1) th at increases SUMOylated proteins in PC3 cells

in vivo

Momordin Ic (12.5, 25, 50 mg/kg, p.o.) accelerates gastrointestinal transport and inhibits gastric emptying in mice by stimulating the synthesis of serotonin (5-HT)[4]. Momordin Ic (10 mg/kg, p.o.) can inhibit ethanol induced gastric mucosal lesions in rats[5]. Momordin Ic (30 mg/kg, once a day for 14 days, p.o.) can reduce CCl4-induced hepatotoxicity in rats[6].

Animal Model:Male ddY mice[4].
Dosage:12.5, 25, 50 mg/kg
Administration:Oral gavage (p.o.)
Result:Accelerated gastrointestinal transit in fasted mice.
Animal Model:Male Sprague-Dawley rat[5].
Dosage:10 mg/kg
Administration:Oral gavage (p.o.)
Result:Reduced the length of the lesions.
Animal Model:Male Sprague–Dawley rat[6].
Dosage:30 mg/kg
Administration:Oral gavage (p.o.), once a day for 14 days
Result:Reduced serum transaminase, lactic dehydrogenase, and γ-glutamyltransferase levels in the CCl4-treated rats.

MOMORDINICSupplier

Cheng Du Pufeide Biotechnology Co., Ltd. Gold
Tel
028-82610909 13388174823
Email
scglp@glp-china.com
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Email
sales@BioChemBest.com
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Email
cdhxsj@163.com
Shenzhen Sungening Bio-Tech Co., Ltd
Tel
+86-0755-89668383
Email
sales@sungening.com
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
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