Catalpalactone Chemical Properties

Melting point:

110-111 °C

Boiling point:

467.1±45.0 °C(Predicted)

Density 

1.269±0.06 g/cm3(Predicted)

solubility 

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

form 

Powder

LogP

2.050 (est)

Catalpalactone Usage And Synthesis

Uses

Catalpalactone has anti-inflammatory effect. Catalpalactone inhibits LPS-induced NO production and iNOS expression in RAW264.7 cells, and also inhibits IRF3, NF-κB, and IFN-β/STAT-1 activation. Catalpalactone also inhibits dopamine biosynthesis by reducing tyrosine hydroxylase (TH) and aromatic-l-amino acid decarboxylase (AADC) activities[1][2].

Definition

ChEBI: Catalpalactone is a member of 2-benzofurans.

target

cAMP | NO

References

[1] Kim HY, et al. Anti-Inflammatory Effects of Catalpalactone Isolated from Catalpa ovata in LPS-Induced RAW264.7 Cells. Molecules. 2019 Mar 29;24(7):1236. DOI:10.3390/molecules24071236
[2] Huang HS, et al. Effects of catalpalactone on dopamine biosynthesis and L-DOPA-induced cytotoxicity in PC12 cells. Environ Toxicol Pharmacol. 2008 Jul;26(1):86-91. DOI:10.1016/j.etap.2008.02.005

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