Dodecyltriphenylphosphonium bromide Chemical Properties

Melting point:

85-88 °C(lit.)

storage temp. 

RT

solubility 

Soluble in DMSO (50 mg/ml) or ethanol (25 mg/mL)

form 

solid

color 

White

Sensitive 

Hygroscopic

BRN 

3581921

Stability:

Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.

CAS DataBase Reference

15510-55-1(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-37/39

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

Dodecyltriphenylphosphonium bromide Usage And Synthesis

Application

Dodecyltriphenylphosphine bromide is a quaternary phosphine salt, which has a wide range of applications as a Wittig reagent, phase transfer catalyst, and surfactant. Quaternary phosphine salts are also a new generation of highly efficient, broad-spectrum, and low-toxicity bactericides, possessing not only strong bactericidal ability but also low foaming, strong slime-removing ability, and a wide applicable pH range. Dodecyltriphenylphosphine bromide exhibits good bactericidal effects against sulfate-reducing bacteria, but its bactericidal effect against heterotrophic bacteria is relatively poor. Dodecyltriphenylphosphine bromide can be prepared by reacting triphenylphosphine with 1-bromododecane.

Description

Dodecyl-TPP (15510-55-1) is a mitochondria-targeting agent which inhibits mitochondrial function inhibiting oxidative phosphorylation and shifting cell metabolism to glycolysis.1 Potently eradicates cancer stem cells (50 nm to 1 mM) selectively over normal cells1. Synergizes with FDA-approved drugs such as doxycycline and niclosamide as well as natural compounds such as berberine. Selectively inhibits the growth of Gram-positive over Gram-negative bacteria.2

Definition

ChEBI: An organic bromide salt that containing equal numbers of dodecyl(triphenyl)phosphonium cations and bromide anions.

References

[1] nan

Dodecyltriphenylphosphonium bromide(15510-55-1)Related Product Information

• 1-Bromododecane
• Allyl bromide
• Dodecylbenzenesulphonic acid
• Triphenylphosphine hydrobromide
• Dimidium bromide
• Methyltriphenylphosphonium bromide
• tert-dodecylthiol
• Ammonium lauryl sulfate
• 1-Dodecanethiol
• Rocuronium bromide
• Ethidium bromide
• Sodium bromate
• 1-Dodecanol
• CALCIUM DODECYLBENZENE SULFONATE
• Vecuronium bromide
• Sodium lauroylsarcosinate
• Tetraphenylphosphonium bromide
• Methyl bromide