18alpha-Glycyrrhetinic acid Chemical Properties

Melting point:

331-333°C

Boiling point:

492.11°C (rough estimate)

Density 

0.9967 (rough estimate)

refractive index 

1.4800 (estimate)

storage temp. 

2-8°C

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Solid

pka

4.71±0.70(Predicted)

color 

White to Off-White

LogP

6.570 (est)

CAS DataBase Reference

1449-05-4(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

Safety Statements 

ection

WGK Germany 

3

RTECS 

RK0190000

HS Code 

29189900

MSDS

• Language:English Provider:SigmaAldrich

18alpha-Glycyrrhetinic acid Usage And Synthesis

Chemical Properties

Glycyrrhetinic acid is a kind of glycoside composed of glycyrrhizic acid-ff two molecules glucuronic acid. It appears as white crystalline powder with sweet taste. The sweetness is about 200 times of the sucrose. Its sweetness is different from other sweeteners such as sucrose. After eating, you can sense the sweetness only after a few moments but the retention time is long. Combination of a small amount of glycyrrhizin and sucrose can save 20% sucrose without affecting the sweetness. Although having no aroma, it has incense effect. It has a melting point (decomposition) of 220 ° C. The aqueous solution is weakly acidic and can be treated by acid.

Uses

Sweeteners; sweetness improving agents; flavor enhancers (dairy products, cocoa products, egg products, mutton), flavoring agents (function well especially when used in combination with salt), Chinese folk mostly use it in sauce and sauce products, pickled goods and so on.

Uses

18α-Glycyrrhetinic acid may be used to synthesize:

• 3-keto-18α-glycyrrhetinic acid
• methyl esters of 18α-glycyrrhetinic acid
• methyl esters of 3-keto-18α-glycyrrhetinic acid

General Description

18α-Glycyrrhetinic acid (18α-GA) is a bioactive triterpenoid found in licorice. It shows selective inhibition of 11-HSD1 (11-hydroxysteroid dehydrogenase 1). It also shows anti-proliferative and apoptotic effect on hepatic stellate cells (HSCs).

18alpha-Glycyrrhetinic acid(1449-05-4)Related Product Information

• 5-CAPROLEIC ACID
• 18alpha-Glycyrrhetinic acid
• 5-METHYL-2-HEPTEN-4-ONE
• trans-4-Ethylcyclohexanecarboxylic acid
• 16-HYDROXYHEXADECANOIC ACID
• 4-CYCLOHEXYLBUTYRIC ACID
• Diammonium glycyrrhizinate
• trans-4-Hexylcyclohexanecarboxylic acid
• 3,5-Dimethyl-2-cyclohexen-1-one
• PIPERITONE
• Celery ketone
• 15-METHYLHEXADECANOIC ACID
• 3-Methyl-5-hexyl-2-cyclohexen-1-one
• Neodecanoic acid
• 4-BUTYLCYCLOHEXANE CARBOXYLIC ACID
• Carbenoxolone disodium
• 18β-Glycyrrhetinic Acid
• Glycyrrhetinic acid sodium salt