4-METHOXYDIPHENYLMETHANE Chemical Properties

Density 

1,05 g/cm³

storage temp. 

Sealed in dry,Room Temperature

form 

oil (Low melting solid)

color 

colorless

Safety Information

Hazard Codes 

Xi,N

Risk Statements 

36/37/38-50/53-41-37/38

Safety Statements 

26-36/37/39-61-60-39

RIDADR 

UN 3077 9 / PGIII

WGK Germany 

3

4-METHOXYDIPHENYLMETHANE Usage And Synthesis

Uses

4-MDM (4-Methoxydiphenylmethane) is an orally active anti-inflammatory compound that selectively enhances the Leukotriene A4 Hydrolase (LTA4H) aminopeptidase enzyme activity. 4-MDM reduces the neutrophil recruitment in the lung by enhancing the degradation of proline-glycine-proline by LTA4H, thereby reducing inflammation, and does not affect the epoxy-hydrolase activity of LTA4H. 4-MDM can be used for research on lung diseases[1].

Synthesis Reference(s)

Tetrahedron Letters, 28, p. 2387, 1987 DOI: 10.1016/S0040-4039(00)96131-8

References

[1] Farhan N, et al. Ultrapressure liquid chromatography-tandem mass spectrometry assay using atmospheric pressure photoionization (UPLC-APPI-MS/MS) for quantification of 4-methoxydiphenylmethane in pharmacokinetic evaluation. J Pharm Biomed Anal. 2016 Sep 5;128:46-52. DOI:10.1016/j.jpba.2016.05.014

4-METHOXYDIPHENYLMETHANE(834-14-0)Related Product Information

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