Polyinosinic acid
Polyinosinic acid Basic information
- Product Name:
- Polyinosinic acid
- Synonyms:
-
- polyinosinicacidpot.salt
- POLY[I] POTASSIUM SALT
- POLYINOSINIC ACID (5') POTASSIUM SALT
- POLYINOSINIC ACID POTASSIUM SALT
- POLYINOSINIC ACID TRIPOTASSIUM SALT
- POLY RL POTASSIUM SALT
- POLYINOSINIC ACID POT. SALT, LYOPH., MR ~1200000
- 5'-Inosinic acid polymers
- CAS:
- 30918-54-8
- MF:
- C10H13N4O8P
- MW:
- 348.21
- EINECS:
- 1592732-453-0
- Product Categories:
-
- Material
- Nucleoside Mono
- Mol File:
- 30918-54-8.mol
Polyinosinic acid Chemical Properties
- storage temp.
- −20°C
- solubility
- Methanol (Slightly), Water (Sparingly)
- form
- Solid
- color
- White to Off-White
- InChI
- InChI=1/C10H13N4O8P/c15-6-4(1-21-23(18,19)20)22-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,11,12,17)(H2,18,19,20)/t4-,6-,7-,10-/s3
- InChIKey
- GRSZFWQUAKGDAV-BFXIWLNFNA-N
- SMILES
- O[C@@H]1[C@@H]([C@@H](COP(O)(O)=O)O[C@H]1N1C=NC2C(NC=NC1=2)=O)O |&1:1,2,3,11,r|
Safety Information
- WGK Germany
- 3
- F
- 3-10-21
MSDS
- Language:English Provider:SigmaAldrich
Polyinosinic acid Usage And Synthesis
Description
Polyinosinic acid Polycytidylic Acid, Sodium Salt, Double-Stranded is a TLR3 (Toll-like receptor 3) agonist. Known to induce interferon production. Hypochromicity: ≥40% at 248 nm. Extinction coefficient = 5000 M-1cm-1 at 260 nm, pH 7.0. Agent for generation of stable, mature dendritic cells (DC) and immunostimulant.
Chemical Properties
White or off-white powder, soluble in water, insoluble in organic solvents such as ethanol and acetaminophen.
Uses
Polyinosinic Acid is an oligolysines used in nucleic acid binding and other biomedical applications.
Application
Polyinosinic acid (Poly(I)) is a homopolymer of inosine that may be used with polycytidylic acid (poly(C)) to form the double-stranded homopolymer (Poly(I).Poly(C)). TLR3 recognizes double-stranded RNA and is a major effector of the immune response against viral pathogens. (Poly(I).Poly(C)) is a used as a model RNA to study cell signaling at the level of TLR3. Poly(IC) is a TRIF-dependent toll-like receptor-3 (TLR3) ligand.
Polyinosinic acidSupplier
- Tel
- 86-571-82358004 13588879771
- sales1@weitai-pharmaceutical.com
- Tel
- 021-021-58432009 400-005-6266
- sales8178@energy-chemical.com
- Tel
- 86-027-88774375
- mwmwhot@163.com
- Tel
- 15527768850
- 1791901229@qq.com
- Tel
- 010-82954736 13391601435
- sales@isomersyn.com
Polyinosinic acid(30918-54-8)Related Product Information
- EPA
- Poly(L-lysine hydrobromide)
- Citric acid
- Folic acid
- Ethyl 2-(Chlorosulfonyl)acetate
- Disodium 5'-Inosinate
- Isoprinosine
- Stearic acid
- Ascoric Acid
- Inosine
- Polyinosinic-polycytidylic acid sodium salt
- POLYINOSINIC ACID POLYCYTIDYLIC ACID,POLYINOSINIC ACID . POLYCYTIDYLIC ACID, LYOPHILIZED
- Inosinic Acid
- Polyinosinic acid . Polycytidylic acid potassium salt,polyinosinic acid/ polycytidylic potassium
- POLYINOSINIC ACID (5') POTASSIUM SALT
- Polyinosinic acid
- 5'-POLYINOSINIC ACID DISODIUM SALT = 5'-POLYI-NA2
- POLYMERS