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Polyinosinic acid

Basic information Safety Supplier Related

Polyinosinic acid Basic information

Product Name:
Polyinosinic acid
Synonyms:
  • polyinosinicacidpot.salt
  • POLY[I] POTASSIUM SALT
  • POLYINOSINIC ACID (5') POTASSIUM SALT
  • POLYINOSINIC ACID POTASSIUM SALT
  • POLYINOSINIC ACID TRIPOTASSIUM SALT
  • POLY RL POTASSIUM SALT
  • POLYINOSINIC ACID POT. SALT, LYOPH., MR ~1200000
  • 5'-Inosinic acid polymers
CAS:
30918-54-8
MF:
C10H13N4O8P
MW:
348.21
EINECS:
1592732-453-0
Product Categories:
  • Material
  • Nucleoside Mono
Mol File:
30918-54-8.mol
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Polyinosinic acid Chemical Properties

storage temp. 
−20°C
solubility 
Methanol (Slightly), Water (Sparingly)
form 
Solid
color 
White to Off-White
InChI
InChI=1/C10H13N4O8P/c15-6-4(1-21-23(18,19)20)22-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,11,12,17)(H2,18,19,20)/t4-,6-,7-,10-/s3
InChIKey
GRSZFWQUAKGDAV-BFXIWLNFNA-N
SMILES
O[C@@H]1[C@@H]([C@@H](COP(O)(O)=O)O[C@H]1N1C=NC2C(NC=NC1=2)=O)O |&1:1,2,3,11,r|
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Safety Information

WGK Germany 
3
3-10-21

MSDS

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Polyinosinic acid Usage And Synthesis

Description

Polyinosinic acid Polycytidylic Acid, Sodium Salt, Double-Stranded is a TLR3 (Toll-like receptor 3) agonist. Known to induce interferon production. Hypochromicity: ≥40% at 248 nm. Extinction coefficient = 5000 M-1cm-1 at 260 nm, pH 7.0. Agent for generation of stable, mature dendritic cells (DC) and immunostimulant.

Chemical Properties

White or off-white powder, soluble in water, insoluble in organic solvents such as ethanol and acetaminophen.

Uses

Polyinosinic Acid is an oligolysines used in nucleic acid binding and other biomedical applications.

Application

Polyinosinic acid (Poly(I)) is a homopolymer of inosine that may be used with polycytidylic acid (poly(C)) to form the double-stranded homopolymer (Poly(I).Poly(C)). TLR3 recognizes double-stranded RNA and is a major effector of the immune response against viral pathogens. (Poly(I).Poly(C)) is a used as a model RNA to study cell signaling at the level of TLR3. Poly(IC) is a TRIF-dependent toll-like receptor-3 (TLR3) ligand.

Polyinosinic acidSupplier

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