Polyinosinic acid Chemical Properties

storage temp. 

−20°C

solubility 

Methanol (Slightly), Water (Sparingly)

form 

Solid

color 

White to Off-White

InChI

InChI=1/C10H13N4O8P/c15-6-4(1-21-23(18,19)20)22-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,11,12,17)(H2,18,19,20)/t4-,6-,7-,10-/s3

InChIKey

GRSZFWQUAKGDAV-BFXIWLNFNA-N

SMILES

O[C@@H]1[C@@H]([C@@H](COP(O)(O)=O)O[C@H]1N1C=NC2C(NC=NC1=2)=O)O |&1:1,2,3,11,r|

Safety Information

WGK Germany 

3

F 

3-10-21

MSDS

• Language:English Provider:SigmaAldrich

Polyinosinic acid Usage And Synthesis

Description

Polyinosinic acid Polycytidylic Acid, Sodium Salt, Double-Stranded is a TLR3 (Toll-like receptor 3) agonist. Known to induce interferon production. Hypochromicity: ≥40% at 248 nm. Extinction coefficient = 5000 M-1cm-1 at 260 nm, pH 7.0. Agent for generation of stable, mature dendritic cells (DC) and immunostimulant.

Chemical Properties

White or off-white powder, soluble in water, insoluble in organic solvents such as ethanol and acetaminophen.

Uses

Polyinosinic Acid is an oligolysines used in nucleic acid binding and other biomedical applications.

Application

Polyinosinic acid (Poly(I)) is a homopolymer of inosine that may be used with polycytidylic acid (poly(C)) to form the double-stranded homopolymer (Poly(I).Poly(C)). TLR3 recognizes double-stranded RNA and is a major effector of the immune response against viral pathogens. (Poly(I).Poly(C)) is a used as a model RNA to study cell signaling at the level of TLR3. Poly(IC) is a TRIF-dependent toll-like receptor-3 (TLR3) ligand.

benefits

Polyinosinic acid has antiviral, anti-tumor, lymphocyte immune function enhancement and nucleic acid metabolism inhibition effects.

Physiological effects

Polyinosinic acid is a single stranded homonucleic acid, which is a Toll-like Receptor 3 (TLR3) ligand. Polyinosinic acid enhances cellular immune response through TLR3 and TRIF. 

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