POLYINOSINIC-POLYCYTIDYLIC ACID POTASSIUM SALT
POLYINOSINIC-POLYCYTIDYLIC ACID POTASSIUM SALT Basic information
- Product Name:
- POLYINOSINIC-POLYCYTIDYLIC ACID POTASSIUM SALT
- Synonyms:
-
- PolyI：C-K
- POLY[I] POLY[C] POTASSIUM SALT
- POLYINOSINIC-POLYCYTIDYLIC ACID POTASSIUM SALT
- Polyinosinic acid . Polycytidylic acid potassium salt
- polyinosinic-polycytidylic acid*potassium
- polyinosinic acid/ polycytidylic potassium
- Poly I：C PotassiuM Salt
- 5'-Cytidylic acid homopolymer complex with 5'-inosinic acid homopolyme potassium salt
- CAS:
- 31852-29-6
- MF:
- C19H27KN7O16P2*
- MW:
- 710.500802
- Product Categories:
-
- Biochemicals and Reagents
- Biomaterials
- Cell Culture
- Materials Science
- Nucleosides
- Nucleotides
- Oligonucleotide Polymers and Copolymers
- Oligonucleotides
- Other adjuvants
- Synthetic Oligonucleotides and Related Reagents
- Vaccine Adjuvants
- Vaccine Production
- Mol File:
- 31852-29-6.mol
POLYINOSINIC-POLYCYTIDYLIC ACID POTASSIUM SALT Chemical Properties
- storage temp.
- −20°C
- solubility
- Soluble in DMSO; H2O : 10mg/mL
- form
- lyophilized powder
POLYINOSINIC-POLYCYTIDYLIC ACID POTASSIUM SALT Usage And Synthesis
Uses
Polyinosinic-polycytidylic Acid Potassium Salt triggers apoptosis in some cancer cells.
Uses
(Polyinosinic-polycytidylic acid potassium salt) TLR3 recognizes double-stranded RNA and is a major effector of the immune response against viral pathogens. Polyinosinic–polycytidylic acid (Poly(I) • Poly(C)) is a double-stranded homopolymer used as a model RNA to study cell signaling at the level of TLR3. Poly(IC) is a TRIF-dependent toll-like receptor-3 (TLR3) ligand.
Biological Activity
Transfection of Poly (I:C) into NIT-1 cells has been used as a model of intracellular dsRNA-induced β cell apoptosis. Eighteen hours post transfection, 45% of the cells were apoptotic with an increase in NF-kB, p50/p65 nuclear translocation, and cleavage of caspases 3 and 8, as well as transcriptional induction of caspase 12, Fas, IL-15, and the TNF receptor-associated ligand (TRAIL). It has been suggested th at Poly(I:C) is one of the most appropriate generators of stable mature dendritic cells (DC). These mature DC might generate in vivo effective immune responses after injection due to their ability to secrete bioactive IL-12 after CD40 ligation. Poly (I:C) was used as a potent adjuvant to enhance the specific anti-tumor immune responses against a peptide-based vaccine.
in vivo
Polyinosinic-polycytidylic acid potassium (50 μg; i.v.; on days 3, 6, and 9 after tumor inoculation) shows antitumor activity in NOD/SCID immunodeficient mice[1].
| Animal Model: | NOD/SCID immunodeficient mice (1205Lu cells)[1] |
| Dosage: | 50 μg |
| Administration: | I.v.; on days 3, 6, and 9 after tumor inoculation |
| Result: | Reduced the size of metastases and the total amount of tumor tissue, and the level of human DNA was 50% lower in mice. |
IC 50
TLR3
POLYINOSINIC-POLYCYTIDYLIC ACID POTASSIUM SALTSupplier
- Tel
- 010-82954736 13391601435
- sales@isomersyn.com
- Tel
- 010-56205725
- waley188@sohu.com
- Tel
- 13971561712, 13995564702, 027-50664929
- hbeixys2001@163.com
- Tel
- +1-510-219-6317
- sales@hbcchem.com
- Tel
- 0755-0755-66853366 13670046396
- sales@chem-strong.com
POLYINOSINIC-POLYCYTIDYLIC ACID POTASSIUM SALT(31852-29-6)Related Product Information
- Aluminum acetylacetonate
- Ethyl isocyanoacetate
- COBALT(II) ACETYLACETONATE
- Ferric acetylacetonate
- 2,4-PENTANEDIONE, SILVER DERIVATIVE
- Tosylmethyl isocyanide
- N-BUTYLISOCYANIDE
- METHYL ISOCYANOACETATE
- SALCOMINE
- PHENYLSELENOL
- DICHLORO(ETHYLENEDIAMINE)PLATINUM(II)
- 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE
- Benzyl isocyanide
- TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III)
- Tris(2,4-pentanedionato)chroMiuM(III)
- TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III)
- TERT-BUTYL ISOCYANIDE
- Polyinosinic acid