Abacavir 5’-Phosphate Chemical Properties

Melting point:

189-194°C (dec.)

Boiling point:

749.3±70.0 °C(Predicted)

Density 

1.93±0.1 g/cm3(Predicted)

storage temp. 

-20°C Freezer

solubility 

Methanol, Water

pka

1.91±0.10(Predicted)

form 

Solid

color 

White

Abacavir 5’-Phosphate Usage And Synthesis

Chemical Properties

White Solid

Uses

Abacavir 5’-Phosphate (Abacavir - In House Impurity) is a metabolite of Abacavir (A105000). Abacavir is a carbocyclic 2''-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.

Definition

ChEBI: Abacavir monophosphate is the organic phosphate that is the 5'-monophosphate of abacavir. It has a role as a metabolite. It is a member of 2,6-diaminopurines and an organic phosphate. It is functionally related to an abacavir.

Abacavir 5’-Phosphate(136470-77-4)Related Product Information

• Abacavir
• 2,6-Diaminopurine
• (1R,3S)-3-[2-AMino-6-(cyclopropylaMino)-9H-purin-9-yl]cyclopentaneMethanol
• Abacavir
• 2-Cyclopentene-1-methanol, 4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-, (1R-cis)-
• trans-Abacavir Hydrochloride
• 2-Amino-6-cyclopropylamino-9H-purine
• (1S–4R)-4-(2-amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol hydrochloride
• Abacavir
• Abacavir 5'-Glucuronide
• Abacavir
• Abacavir-d4
• Abacavir Related CoMpound D
• Abacavir Carboxylate
• (1S,4R)-(4-Aminocyclopent-2-enyl)methanol hydrochloride
• Abacavir sulfate
• 6-aminocarbovir
• Abacavir Impurity 1