Abacavir Related CoMpound D Chemical Properties

Boiling point:

830.1±75.0 °C(Predicted)

Density 

1.90±0.1 g/cm3(Predicted)

pka

4.86±0.10(Predicted)

Safety Information

WGK Germany 

3

HS Code 

2933599550

Abacavir Related CoMpound D Usage And Synthesis

Uses

Abacavir 5’-4-Chloro-6-methylpyrimidine-2,5-diamine (Abacavir EP Impurity B) is a degradation product of Abacavir Sulfate (A105000). Abacavir is a carbocyclic 2''-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.

Abacavir Related CoMpound D(1443421-69-9)Related Product Information

• Abacavir sulfate
• 2-Cyclopentene-1-methanol, 4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-, (1R-cis)-
• Abacavir
• (1S–4R)-4-(2-amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol hydrochloride
• 6-aminocarbovir
• Abacavir-d4
• Abacavir
• Abacavir
• trans-Abacavir Hydrochloride
• 2-Amino-6-cyclopropylamino-9H-purine
• (1R,3S)-3-[2-AMino-6-(cyclopropylaMino)-9H-purin-9-yl]cyclopentaneMethanol
• 2,6-Diaminopurine
• Abacavir 5'-Glucuronide
• Abacavir
• Abacavir Carboxylate
• Abacavir 5’-Phosphate
• (1S,4R)-(4-Aminocyclopent-2-enyl)methanol hydrochloride
• Abacavir Impurity 1