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Dehydrocrenatidine

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Dehydrocrenatidine Basic information

Product Name:
Dehydrocrenatidine
Synonyms:
  • Dehydrocrenatidine
  • 9H-Pyrido[3,4-b]indole, 1-ethenyl-4,8-dimethoxy-
  • 1-ethenyl-4,8-dimethoxy-9H-pyrido[3,4-b]indole
  • TOP 3
  • TOP3
  • TOP-3
  • O-Methylpicrasidine I
CAS:
65236-62-6
MF:
C15H14N2O2
MW:
254.28
Mol File:
65236-62-6.mol
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Dehydrocrenatidine Chemical Properties

form 
Solid
color 
Off-white to light yellow
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Dehydrocrenatidine Usage And Synthesis

Uses

Dehydrocrenatidine, a natural alkaloid, is a specific JAK inhibitor. Dehydrocrenatidine inhibits voltage-gated sodium channels and ameliorates mechanic allodia in a rat model of neuropathic pain[1][2].

in vivo

Dehydrocrenatidine inhibits JAK-STAT3 dependent DU145 and MDA-MB-468 cell survival and induces cell apoptosis. Dehydrocrenatidine inhibits JAKs-JH1 domain over-expression induced STAT3 and STAT1 phosphorylations[1].
Dehydrocrenatidine diminishes IL-6, IFNα and IFNγ stimulated STAT3 phosphorylation as well as constitutive STAT3 phosphorylation[1].
DHCT suppresses both tetrodotoxin-resistant (TTX-R) and sensitive (TTX-S) voltage-gated sodium channel (VGSC) currents with IC50 values of 12.36 μM and 4.87 μM, respectively[2].

References

[1] Jing Zhang, et al. Dehydrocrenatidine is a novel janus kinase inhibitor. Mol Pharmacol. 2015 Apr;87(4):572-81. DOI:10.1124/mol.114.095208
[2] Fang Zhao, et al. Dehydrocrenatidine Inhibits Voltage-Gated Sodium Channels and Ameliorates Mechanic Allodia in a Rat Model of Neuropathic Pain. Toxins (Basel). 2019 Apr 18;11(4):229. DOI:10.3390/toxins11040229

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