Basic information Safety Supplier Related

Cibenzoline succinate

Basic information Safety Supplier Related

Cibenzoline succinate Basic information

Product Name:
Cibenzoline succinate
Synonyms:
  • (+-)-2-(2,2-diphenylcyclopropyl)-2-imidazolinesuccinate(1:1)
  • ole(1:1)
  • ritmalan
  • ro22-7796/001
  • succinic acid, compound with 2-(2,2-diphenylcyclopropyl)-4,5-dihydro-1H-imidazole (1:2)
  • 2-(2,2-Diphenylcyclopropyl)-4,5-dihydro-1H-imidazole succinate
  • 2-(2,2-diphenylcyclopropyl)-4,5-dihydro-1H-imidazole succinate, Cibenol, Cipralan, Exacor
  • Cinobezile
CAS:
100678-32-8
MF:
C18H18N2.C4H6O4
MW:
380.44
EINECS:
634-471-4
Product Categories:
  • Heterocyclic Compounds
Mol File:
100678-32-8.mol
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Cibenzoline succinate Chemical Properties

Melting point:
165°
storage temp. 
2-8°C
solubility 
H2O: ≥5mg/mL
form 
solid
color 
white to off-white
Water Solubility 
H2O: ≥5mg/mL
Stability:
Light Sensitive
InChI
1S/C18H18N2.C4H6O4/c1-3-7-14(8-4-1)18(15-9-5-2-6-10-15)13-16(18)17-19-11-12-20-17;5-3(6)1-2-4(7)8/h1-10,16H,11-13H2,(H,19,20);1-2H2,(H,5,6)(H,7,8)
InChIKey
XFUIOIWYMHEPIE-UHFFFAOYSA-N
SMILES
OC(=O)CCC(O)=O.C1CN=C(N1)C2CC2(c3ccccc3)c4ccccc4
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Safety Information

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
3
RTECS 
EJ9960100
Storage Class
11 - Combustible Solids
Hazard Classifications
Acute Tox. 4 Oral
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Cibenzoline succinate Usage And Synthesis

Uses

Cardiac depressant (anti-arrhythmic).

Uses

Cibenzoline Succinate acts as a highly active class I antiarrhythmic agent.

Definition

ChEBI: Cibenzoline succinate is a diarylmethane.

General Description

Cibenzoline also called (±)-2-(2,2-diphenylcyclopropyl)-2-imidazoline succinate, is generally used in stereo combination of R(+) and S(?) forms. It also exhibits anticholinergic activity.. Cibenzoline is known to improve left ventricular diastolic dysfunction by reducing left ventricular pressure gradient.

Biochem/physiol Actions

Cibenzoline is a class IA antiarrhythmic drug. Cibenzoline (μM concentrations) blocks ATP-sensitive K channels in heart and pancreatic cells. Cibenzoline interacts with the channel pore-forming subunit of the K(ATP) channel (Kir6.2) from the cytoplasmic side. Cibenzoline also inhibits the delayed rectifier K current [I(Kr)] in sino-atrial node cells.

Cibenzoline succinateSupplier

Sigma-Aldrich
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021-61415566 800-8193336
Email
orderCN@merckgroup.com
Aikon International Limited
Tel
025-58859352 18068836627
Email
sales01@aikonchem.com
Alfa Chemistry
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+1-5166625404;
Email
Info@alfa-chemistry.com
Career Henan Chemica Co
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+86-0371-86658258 +8613203830695
Email
laboratory@coreychem.com
CONIER CHEM AND PHARMA LIMITED
Tel
+8618523575427
Email
sales@conier.com
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Cibenzoline succinate(100678-32-8)Related Product Information