Cibenzoline succinate
Cibenzoline succinate Basic information
- Product Name:
- Cibenzoline succinate
- Synonyms:
-
- (+-)-2-(2,2-diphenylcyclopropyl)-2-imidazolinesuccinate(1:1)
- ole(1:1)
- ritmalan
- ro22-7796/001
- succinic acid, compound with 2-(2,2-diphenylcyclopropyl)-4,5-dihydro-1H-imidazole (1:2)
- 2-(2,2-Diphenylcyclopropyl)-4,5-dihydro-1H-imidazole succinate
- 2-(2,2-diphenylcyclopropyl)-4,5-dihydro-1H-imidazole succinate, Cibenol, Cipralan, Exacor
- Cinobezile
- CAS:
- 100678-32-8
- MF:
- C18H18N2.C4H6O4
- MW:
- 380.44
- EINECS:
- 634-471-4
- Product Categories:
-
- Heterocyclic Compounds
- Mol File:
- 100678-32-8.mol
Cibenzoline succinate Chemical Properties
- Melting point:
- 165°
- storage temp.
- 2-8°C
- solubility
- H2O: ≥5mg/mL
- form
- solid
- color
- white to off-white
- Stability:
- Light Sensitive
Cibenzoline succinate Usage And Synthesis
Uses
Cardiac depressant (anti-arrhythmic).
Uses
Cibenzoline Succinate acts as a highly active class I antiarrhythmic agent.
Definition
ChEBI: Cibenzoline succinate is a diarylmethane.
General Description
Cibenzoline also called (±)-2-(2,2-diphenylcyclopropyl)-2-imidazoline succinate, is generally used in stereo combination of R(+) and S(?) forms. It also exhibits anticholinergic activity.. Cibenzoline is known to improve left ventricular diastolic dysfunction by reducing left ventricular pressure gradient.
Biochem/physiol Actions
Cibenzoline is a class IA antiarrhythmic drug. Cibenzoline (μM concentrations) blocks ATP-sensitive K channels in heart and pancreatic cells. Cibenzoline interacts with the channel pore-forming subunit of the K(ATP) channel (Kir6.2) from the cytoplasmic side. Cibenzoline also inhibits the delayed rectifier K current [I(Kr)] in sino-atrial node cells.
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Cibenzoline succinate(100678-32-8)Related Product Information
- Cefazolin
- Dioctyl sulfosuccinate sodium salt
- 6alpha-Methylprednisolone sodium succinate
- Cefazolin sodium salt
- Tolazoline hydrochloride
- Dichlorodiphenylsilane
- Metroprolol succinate
- Succinic acid
- iron succinate
- 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one
- Disodium succinate
- Chlorodiphenylphosphine
- Imidazole
- Oxymetazoline hydrochloride
- BUTYRAMIDINE
- Cibenzoline
- Cibenzoline succinate
- 4-methylpentanimidamide