1,2-dioleoyl-sn-glycero-3-phospho-L-serine (sodiuM salt) Chemical Properties

storage temp. 

Store at -20°C

solubility 

Chloroform: 10 mg/ml

form 

A crystalline solid

color 

Light yellow to orange

Water Solubility 

soluble (Insoluble in ethanol and DMSO, soluble in Chloroform:Methanol:Water (65:25:4) at 5mg/mL)

InChIKey

RRLDZFIFYLDDLI-OLZOWLLTNA-N

SMILES

[C@H](COC(=O)CCCCCCC/C=C\CCCCCCCC)(OC(=O)CCCCCCC/C=C\CCCCCCCC)COP(O)(=O)OC[C@H](N)C(=O)O.[NaH] |&1:0,49,r|

1,2-dioleoyl-sn-glycero-3-phospho-L-serine (sodiuM salt) Usage And Synthesis

Description

1,2-Dioleoyl-sn-glycero-3-PS (DOPS) is a phospholipid containing oleic acid (Item Nos. 90260 | 24659) at the sn-1 and sn-2 positions, respectively. Nanovesicles composed of DOPS and the lysosomal protein saposin C (SapC) are cytotoxic to SK-MEL-28 cells in vitro and decrease tumor volume in a squamous cell carcinoma mouse xenograft model. DOPS has been used in the formation of unilamellar vesicles to study the effect of curvature on membrane structure and in the formation of supported lipid bilayers to study the effects of various support materials on lipid redistribution between membrane leaflets.

Uses

1,2-dioleoyl-sn-glycero-3-phospho-L-serine (sodiuM salt) is a lipid being studied in the assembly and long-term stability of solid supported lipid bilayers from artificial and natural lipid mixtures.

References

[1] SHADI ABU-BAKER. Cytotoxicity and Selectivity in Skin Cancer by SapC-DOPS Nanovesicles.[J]. Journal of Cancer Therapy, 2012, 3 4: 321-326. DOI: 10.4236/jct.2012.34041
[2] NORBERT KU?ERKA. Curvature Effect on the Structure of Phospholipid Bilayers[J]. Langmuir, 2006, 23 3: 1292-1299. DOI: 10.1021/la062455t
[3] RALF P. RICHTER  Alain R B  Nicolas Maury. On the Effect of the Solid Support on the Interleaflet Distribution of Lipids in Supported Lipid Bilayers[J]. Langmuir, 2004, 21 1: 299-304. DOI: 10.1021/la0478402

1,2-dioleoyl-sn-glycero-3-phospho-L-serine (sodiuM salt)(90693-88-2)Related Product Information

• 1-PALMITOYL-SN-GLYCERO-3-PHOSPHOCHOLINE
• 1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine
• 1,2-DI 3,7,11,15-TETRAMETHYLHEXADECANOYL-SN-GLYCERO-3-PHOSPHOCHOLINE
• L-BETA,GAMMA-DIPALMITOYL-ALPHA-PHOSPHATIDIC ACID DISODIUM SALT
• L-ALPHA-LYSOPHOSPHATIDYLCHOLINE, STEAROYL
• 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine
• 1-MYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE
• 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE
• 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHO-L-SERINE SODIUM SALT
• 1,2-distearoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (sodiuM salt)
• 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHO-L-SERINE (MONOSODIUM SALT)
• 1,2-DiMyristoyl-sn-glycero-3-phospho-rac-(1-glycerol) SodiuM Salt
• 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHOCHOLINE
• 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHATIDYL-RAC-GLYCEROL, NA SALT
• 1,2-DI[(CIS)-9-OCTADECENOYL]-SN-GLYCEROL-3-PHOSPHO-[1-RAC-GLYCEROL] SODIUM SALT
• 1,2-Distearoyl-sn-glycero-3-phosphocholine
• 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE
• 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE