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tert-Butyl N-hydroxycarbamate

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tert-Butyl N-hydroxycarbamate Basic information

Product Name:
tert-Butyl N-hydroxycarbamate
Synonyms:
  • N-Boc-hydroxylamine, >=98%
  • N-tert-Butoxycarbonylhydroxylamine, 98+%
  • N-(tert-Butoxycarbonyl)hydroxylamine~tert-ButylN-hydroxycarbamate
  • N-(T-BUTOXYCARBONYL)-HYDROXYLAMINE
  • N-T-BOC HYDROXYLAMINE
  • N-HYDROXYCARBAMIC ACID TERT-BUTYL ESTER
  • N-BOC-HYDROXYLAMINE
  • TERT-BUTYL N-HYDROXYCARBAMATE 99.0%
CAS:
36016-38-3
MF:
C5H11NO3
MW:
133.15
EINECS:
252-836-2
Product Categories:
  • Hydroxylamines
  • Hydroxylamines (N-Substituted)
  • INTERMEDIATESOFMEROPENAM
  • API intermediates
  • Naphthyridine,Quinoline
  • 1
Mol File:
36016-38-3.mol
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tert-Butyl N-hydroxycarbamate Chemical Properties

Melting point:
53-55 °C (lit.)
Boiling point:
245.66°C (rough estimate)
Density 
1.2510 (rough estimate)
refractive index 
1.4120 (estimate)
storage temp. 
2-8°C
solubility 
Chloroform, Methanol
pka
9.31±0.23(Predicted)
form 
Crystalline Powder
color 
White to light pink
Water Solubility 
Slightly soluble in water.
Sensitive 
Moisture Sensitive
BRN 
1756546
CAS DataBase Reference
36016-38-3(CAS DataBase Reference)
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Safety Information

Safety Statements 
22-24/25
WGK Germany 
3
21
HS Code 
29280090

MSDS

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tert-Butyl N-hydroxycarbamate Usage And Synthesis

Chemical Properties

White to light pink crystalline powder

Uses

N-Boc-hydroxylamine is used in the preparation of azridines by cycloaddition of azides with nitroso Diels-Alder adducts. It acts as a reagent for the synthesis of hydroxylamine derivatives t-butyl-N-(acyloxy)carbamates and N,O-diacylated N-hydroxyarylsulfonamides.

Uses

tert-Butyl N-hydroxycarbamate is used in the preparation of azridines by cycloaddition of azides with nitroso Diels-Alder adducts.

Synthesis Reference(s)

Journal of the American Chemical Society, 81, p. 955, 1959 DOI: 10.1021/ja01513a049
Tetrahedron Letters, 24, p. 231, 1983 DOI: 10.1016/S0040-4039(00)81372-6

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