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ALPHA-CGRP (8-37) (HUMAN)

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ALPHA-CGRP (8-37) (HUMAN) Basic information

Product Name:
ALPHA-CGRP (8-37) (HUMAN)
Synonyms:
  • calcitoningene-relatedpeptide(8-37
  • VAL-THR-HIS-ARG-LEU-ALA-GLY-LEU-LEU-SER-ARG-SER-GLY-GLY-VAL-VAL-LYS-ASN-ASN-PHE-VAL-PRO-THR-ASN-VAL-GLY-SER-LYS-ALA-PHE-NH2
  • Alpha-CGRP (8-37) (human) trifluoroacetate salt
  • calcitonin gene related peptide*fragment 8-37 hum
  • A-CGRP (8-37) (HUMAN)
  • α-cgrp 8-37
  • ALA-CYS-ASN-THR-ALA-THR-CYS-VAL-THR-HIS-ARG-LEU-ALA-ASP-PHE-LEU-SER-ARG-SER-GLY-GLY-VAL-GLY-LYS-ASN-ASN-PHE-VAL-PRO-THR-ASN-VAL-GLY-SER-LYS-ALA-PHE-NH2: ACNTATCVTHRLADFLSRSGGVGKNNFVPTNVGSKAF-NH2DISULFIDE BRIDGE CYS2-CYS7
  • 8-Val-37-Phe-calcitonin gene-related peptide
CAS:
119911-68-1
MF:
C139H230N44O38
MW:
3125.59
EINECS:
232-693-2
Product Categories:
  • Peptide
  • Calcitonin and CGRP receptor
Mol File:
119911-68-1.mol
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ALPHA-CGRP (8-37) (HUMAN) Chemical Properties

Density 
1.46±0.1 g/cm3(Predicted)
storage temp. 
-20°C
form 
powder
color 
White to off-white
Water Solubility 
Soluble to 0.50 mg/ml in sterile water
Sequence
H-Val-Thr-His-Arg-Leu-Ala-Asp-Phe-Leu-Ser-Arg-Ser-Gly-Gly-Val-Gly-Lys-Asn-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe-NH2
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Safety Information

WGK Germany 
3

MSDS

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ALPHA-CGRP (8-37) (HUMAN) Usage And Synthesis

Uses

Calcitonin Gene Related Peptide Fragment 8-37 human has been used in the administration of drugs. It has been used to test the hypothesis that calcitonin gene‐related peptide (CGRP) plays a role in the fetal cardiovascular and metabolic defense responses to acute hypoxaemia by affecting sympathetic outflow.

General Description

Calcitonin-related peptide α (CALCA) is a 37-amino-acid vasoactive neuropeptide. It is scattered in the central and peripheral nervous systems. The calcitonin/calcitonin gene-related peptide gene complex codes for a small family of peptides: calcitonin, katacalcin and CALCA. This vasodilator is potent than other vasodilators, such as adenosine, substance P or acetylcholine. CALCA gene is located on human chromosome 11p15.2-p15.1. Procalcitonin (PCT) is a calcitonin (CT) precursor.

Biochem/physiol Actions

Selective competitive antagonist at CGRP receptors, but not at calcitonin receptors.Calcitonin gene-related peptide (CALCA) serves as a proangiogenic growth factor in the development of human placenta. Mutations of CALCA gene is associated with Parkinson′s disease, ovarian cancer and essential hypertension. CALCA induce vascular endothelial cell proliferation, migration and capillary-like tube formation.

storage

Store at -20°C

ALPHA-CGRP (8-37) (HUMAN)Supplier

3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Email
3bsc@sina.com
GL Biochem (Shanghai) Ltd
Tel
21-61263452 13641803416
Email
ymbetter@glbiochem.com
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Hunan Hui Bai Shi Biotechnology Co., Ltd.
Tel
0731-85526065 13308475853
Email
ivy@hnhbsj.com