ALPHA-CGRP (RAT)
ALPHA-CGRP (RAT) Basic information
- Product Name:
- ALPHA-CGRP (RAT)
- Synonyms:
-
- ALPHA-CALCITONIN GENE RELATED PEPTIDE, RAT
- ALPHA-CGRP (RAT)
- CALCITONIN GENE RELATED PEPTIDE RAT
- H-SER-CYS-ASN-THR-ALA-THR-CYS-VAL-THR-HIS-ARG-LEU-ALA-GLY-LEU-LEU-SER-ARG-SER-GLY-GLY-VAL-VAL-LYS-ASP-ASN-PHE-VAL-PRO-THR-ASN-VAL-GLY-SER-GLU-ALA-PHE-NH2
- H-SER-CYS-ASN-THR-ALA-THR-CYS-VAL-THR-HIS-ARG-LEU-ALA-GLY-LEU-LEU-SER-ARG-SER-GLY-GLY-VAL-VAL-LYS-ASP-ASN-PHE-VAL-PRO-THR-ASN-VAL-GLY-SER-GLU-ALA-PHE-NH2 (DISULFIDE BRIDGE: 2-7)
- CGRP (RAT)
- SCNTATCVTHRLAGLLSRSGGVVKDNFVPTNVGSEAF-NH2 (DISULFIDE BRIDGE: 2-7)
- SER-CYS-ASN-THR-ALA-THR-CYS-VAL-THR-HIS-ARG-LEU-ALA-GLY-LEU-LEU-SER-ARG-SER-GLY-GLY-VAL-VAL-LYS-ASP-ASN-PHE-VAL-PRO-THR-ASN-VAL-GLY-SER-GLU-ALA-PHE-NH2
- CAS:
- 83651-90-5
- MF:
- C162H262N50O52S2
- MW:
- 3806.24748
- Product Categories:
-
- Peptide
- Mol File:
- 83651-90-5.mol
ALPHA-CGRP (RAT) Chemical Properties
- storage temp.
- −20°C
- form
- powder
- color
- White to off-white
- Water Solubility
- Soluble to 0.80 mg/ml in water
- Sequence
- H-Ser-Cys-Asn-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asp-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Glu-Ala-Phe-NH2 (Disulfide bridge:Cys2-Cys7)
MSDS
- Language:English Provider:SigmaAldrich
ALPHA-CGRP (RAT) Usage And Synthesis
Uses
α-CGRP (mouse, rat), a neuropeptide (calcitonin gene-related peptide (CGRP)) mainly expressed in neuromuscular junction, is a potent vasodilator. α-CGRP (mouse, rat) can lead to a fall in blood pressure and an increase in heart rate by peripheral administration, also relax colonie smooth muscle. α-CGRP (mouse, rat) has the potential in cardiovascular, pro-inflammatory, migraine and metabolic studies[1][2][3][4].
in vivo
α-CGRP (mouse, rat) (0.25, 0.5, 1 μg/kg/min, intravenous) dose-dependent decreases mean arterial blood pressure, while heart rate and systemic vascular conduction increased, while cardiac output remained unchanged[3].
α-CGRP (mouse, rat) plays an important role in the regulation of Kainic acid (KA) induced pyramid-cell death in hippocampal CA3 region[4].
storage
Store at -20°C
References
[1] Whitby K, et al. Castanospermine, a potent inhibitor of dengue virus infection in vitro and in vivo. J Virol. 2005 Jul;79(14):8698-706. DOI:10.1128/JVI.79.14.8698-8706.2005
[2] Xu H, et al. Transcriptional Atlas of Intestinal Immune Cells Reveals that Neuropeptide α-CGRP Modulates Group 2 Innate Lymphoid Cell Responses. Immunity. 2019 Oct 15;51(4):696-708.e9. DOI:10.1016/j.immuni.2019.09.004
[3] Arulmani U, et al. Effects of the calcitonin gene-related peptide (CGRP) receptor antagonist BIBN4096BS on alpha-CGRP-induced regional haemodynamic changes in anaesthetised rats. Basic Clin Pharmacol Toxicol. 2004 Jun;94(6):291-7. DOI:10.1111/j.1742-7843.2004.pto940606.x
[4] Park SH, et al. Role of α-CGRP in the regulation of neurotoxic responses induced by kainic acid in mice. Peptides. 2013 Jun;44:158-62. DOI:10.1016/j.peptides.2013.04.001
ALPHA-CGRP (RAT)Supplier
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- 821-50328103-801 18930552037
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- info@cellmano.com
ALPHA-CGRP (RAT)(83651-90-5)Related Product Information
- CALCITONIN (PORCINE)
- CALCITONIN, RAT
- ALPHA-CGRP (8-37) (HUMAN)
- Calcitonin Gene Related Peptide, chicken
- CALCITONIN, HUMAN
- METHYL ISOCYANOACETATE
- Aluminum acetylacetonate
- Ethyl isocyanoacetate
- Cupric acetylacetonate
- TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III)
- Calcitonin
- N-BUTYLISOCYANIDE
- TERT-BUTYL ISOCYANIDE
- Tris(2,4-pentanedionato)chroMiuM(III)
- PHENYLSELENOL
- Tosylmethyl isocyanide
- COBALT(II) ACETYLACETONATE
- 2,4-PENTANEDIONE, SILVER DERIVATIVE