WAY 208466 dihydrochloride Chemical Properties

storage temp. 

Desiccate at -20°C

solubility 

Soluble to 80 mM in water and to 80 mM in DMSO

form 

Powder

color 

Off-white to light yellow

Water Solubility 

H2O: 5mg/mL, clear (warmed)

InChI

1S/C17H18FN3O2S/c1-20(2)9-10-21-12-16(15-7-4-8-19-17(15)21)24(22,23)14-6-3-5-13(18)11-14/h3-8,11-12H,9-10H2,1-2H3

InChIKey

SFSFIDVAEMDPIP-UHFFFAOYSA-N

SMILES

CN(C)CCN1C=C(S(C2=CC=CC(F)=C2)(=O)=O)C3=CC=CN=C31

Safety Information

WGK Germany 

WGK 3

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

WAY 208466 dihydrochloride Usage And Synthesis

Uses

3-[(3-Fluorophenyl)sulfonyl]-N,N-dimethyl-1H-pyrrolo[2,3-b]pyridine-1-ethanamine Dihydrochloride is the dihydrochloride salt of 3-[(3-Fluorophenyl)sulfonyl]-N,N-dimethyl-1H-pyrrolo[2,3-b]pyridine-1-ethanamine which is a selective 5-HT6 receptor agonist. It has been proven to have antidepressant and anxiolytic effects on rats suggesting its usefulness as a potential antidepressant.

Biological Activity

WAY-208466 is a high affinity (Ki = 4.8 nM) 5-HT6 receptor agonist. In HeLa cells expressing cloned human 5-HT6, the compound induced cAMP production (EC50 = 7.3 nM; Emax = 100%). WAY-208466 increases cortical GABA levels and exhibits anxiolytic activity in r at studies.

storage

Desiccate at RT

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