MAY-262611
MAY-262611 Basic information
- Product Name:
- MAY-262611
- Synonyms:
-
- 1-[4-(2-Naphthalenyl)-2-pyrimidinyl]-4-piperidinemethanamine MAY-262611
- MAY-262611
- DKK1
- 4-PiperidineMethanaMine, 1-[4-(2-naphthalenyl)-2-pyriMidinyl]-
- WAY-262611
- 1-[4-(2-Naphthalenyl)-2-pyrimidinyl]-4-piperidinemethanamine
- 1-{1-[4-(2-Naphthyl)-2-pyrimidinyl]-4-piperidinyl}methanamine
- Wnt/β-catenin
- CAS:
- 1123231-07-1
- MF:
- C20H22N4
- MW:
- 318.42
- EINECS:
- 604-604-1
- Product Categories:
-
- Inhibitors
- Mol File:
- 1123231-07-1.mol
MAY-262611 Chemical Properties
- Boiling point:
- 544.8±42.0 °C(Predicted)
- Density
- 1.169±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 50 mg/ml; Ethanol:PBS (pH 7.2) (1:1): 0.5 mg/ml
- form
- Powder
- pka
- 10.13±0.29(Predicted)
- color
- Light yellow to yellow
MAY-262611 Usage And Synthesis
Uses
WAY-262611 is a Wnt/β-Catenin agonist that increases bone formation rate with an EC50 of 0.63 μM in TCF-Luciferase assay. WAY-262611 is also a Dkk1 inhibitor[1].
Definition
ChEBI: [1-[4-(2-naphthalenyl)-2-pyrimidinyl]-4-piperidinyl]methanamine is a member of naphthalenes.
in vivo
WAY-262611 has excellent pharmacokinetic properties and shows a dose dependent increase in the trabecular bone formation rate in ovariectomized rats following oral administration. Calvariae from wt mice treated with WAY-262611 shows statistically increased BFR, while similarly treated KO animals are no different from control. This indicates that WAY-262611 is acting via the Wntβ-catenin pathway and most likely through inhibition of Dkk-1[1].
References
[1] Pelletier JC, et al. (1-(4-(Naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine: a wingless beta-catenin agonist that increases bone formation rate. J Med Chem. 2009 Nov 26;52(22):6962-5. DOI:10.1021/jm9014197
[2] L Enochson, et al. GDF5 reduces MMP13 expression in human chondrocytes via DKK1 mediated canonical Wnt signaling inhibition. Osteoarthritis Cartilage. 2014 Apr;22(4):566-77. DOI:10.1016/j.joca.2014.02.004
MAY-262611Supplier
- Tel
- sales@boylechem.com
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- +86-21-20908456
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- +86 21 61551611
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- 021-58950125
- info@chemexpress.com
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- 021-50840321, 18601625411
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