Isocoptisine acetate
Isocoptisine acetate Basic information
- Product Name:
- Isocoptisine acetate
- Synonyms:
-
- Isocoptisine acetate
- Pseudocoptisine acetate
- CAS:
- 30426-66-5
- MF:
- C21H17NO6
- MW:
- 379.37
- Mol File:
- 30426-66-5.mol
Isocoptisine acetate Chemical Properties
- Melting point:
- 146-147 °C
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
Isocoptisine acetate Usage And Synthesis
Uses
Pseudocoptisine (Isocoptisine) acetate is a quaternary alkaloid with benzylisoquinoline skeleton, was isolated from Corydalis Tuber. Pseudocoptisine acetate inhibits acetylcholinesterase (AChE) activity with an IC50 of 12.8 μM. Anti-inflammatory and anti-amnestic effects[1][2].
in vivo
The anti-amnesic activities of Pseudocoptisine in mice on the learning and memory impairments induced by scopolamine (1.0 mg/kg, i.p.) are examined. Pseudocoptisine (2.0 mg/kg, p.o.) significantly reverses cognitive impairments in mice by passive avoidance test[1].
References
[1] Hung TM, et al. Anti-amnestic activity of pseudocoptisine from Corydalis Tuber. Biol Pharm Bull. 2008;31(1):159-162. DOI:10.1248/bpb.31.159
[2] Yun KJ, et al. Quaternary alkaloid, pseudocoptisine isolated from tubers of Corydalis turtschaninovi inhibits LPS-induced nitric oxide, PGE(2), and pro-inflammatory cytokines production via the down-regulation of NF-kappaB in RAW 264.7 murine macrophage c DOI:10.1016/j.intimp.2009.08.001
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