Basic information Safety Supplier Related

(+/-)-PROPIONYLCARNITINE CHLORIDE

Basic information Safety Supplier Related

(+/-)-PROPIONYLCARNITINE CHLORIDE Basic information

Product Name:
(+/-)-PROPIONYLCARNITINE CHLORIDE
Synonyms:
  • (+/-)-PROPIONYLCARNITINE CHLORIDE
  • Propionyl Carnitine
  • 3-propanoyloxy-4-trimethylammonio-butanoate
  • 1-Propanaminium, 3-carboxy-N,N,N-trimethyl-2-(1-oxopropoxy)-, inner salt
  • 3-Carboxy-N,N,N-trimethyl-2-(1-oxopropoxy)-1-propanaminium inner salt
  • Hsdb 7589
  • (+/-)-Propionylcarnitinechloride
  • O-propanoyl-L-carnitine
CAS:
17298-37-2
MF:
C10H19NO4
MW:
217.27
Product Categories:
  • Lipid signaling
Mol File:
17298-37-2.mol
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(+/-)-PROPIONYLCARNITINE CHLORIDE Chemical Properties

storage temp. 
Desiccate at RT
solubility 
DMSO: 125 mg/mL (575.35 mM)
form 
Solid
color 
White to off-white
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Safety Information

Hazardous Substances Data
17298-37-2(Hazardous Substances Data)
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(+/-)-PROPIONYLCARNITINE CHLORIDE Usage And Synthesis

Uses

Propionylcarnitine is metabolized by carnitine acetyltransferase from propionyl-CoA. Increased propionylcarnitine is regarded as a biomarker of vitamin B12 deficiency[1][2].

Definition

ChEBI: O-propanoylcarnitine is an O-acylcarnitine compound having propanoyl as the acyl substituent. It has a role as an analgesic, an antirheumatic drug, a cardiotonic drug, a peripheral nervous system drug and a human metabolite. It is functionally related to a propionic acid.

in vivo

Propionylcarnitine (2 mM/kg; p.o. for 4 weeks) affects plasma and urine total carnitine concentrations of mice[3].

Animal Model:Adult age-matched male C57BL/6 mice[5]
Dosage:2 mM/kg/day
Administration:Oral gavage; 2 mM/kg/day for 4 weeks
Result:Increased plasma and urine total carnitine concentrations, but showed no effect on the skeletal muscle carnitine content of mice.

IC 50

Human Endogenous Metabolite

References

[1] Jacobs PL, et al. Glycine propionyl-L-carnitine produces enhanced anaerobic work capacity with reduced lactate accumulation in resistance trained males. J Int Soc Sports Nutr. 2009;6:9. Published 2009 Apr 2. DOI:10.1186/1550-2783-6-9
[2] Kowal A, et al. Propionylcarnitine and methionine concentrations in newborns with hypospadias. Cent European J Urol. 2013;66(3):377-380. DOI:10.5173/ceju.2013.03.art36
[3] Palmieri L, et al. Protection of beta-thalassaemic erythrocytes from oxidative stress by propionyl carnitine. Int J Tissue React. 1994;16(3):121-9. PMID:7852033
[4] Tassani V, et al. Anaplerotic effect of propionyl carnitine in rat heart mitochondria. Biochem Biophys Res Commun. 1994 Mar 15;199(2):949-53. DOI:10.1006/bbrc.1994.1321
[5] Morand R, et al. Effect of carnitine, acetyl-, and propionylcarnitine supplementation on the body carnitine pool, skeletal muscle composition, and physical performance in mice. Eur J Nutr. 2014 Sep;53(6):1313-25. DOI:10.1007/s00394-013-0631-6
[6] Bertelli A, et al. Effect of propionyl carnitine on energy charge and adenine nucleotide content of cardiac endothelial cells during hypoxia. Int J Tissue React. 1991;13(1):37-40. PMID:1889961

(+/-)-PROPIONYLCARNITINE CHLORIDESupplier

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