42-O-[(1,1-Dimethylethyl)dimethylsilyl]rapamycin Chemical Properties

Boiling point:

977.0±75.0 °C(Predicted)

Density 

1.12±0.1 g/cm3(Predicted)

storage temp. 

-20°C Freezer

solubility 

Dichloromethane, Methanol

form 

Solid

pka

10.40±0.70(Predicted)

color 

White

42-O-[(1,1-Dimethylethyl)dimethylsilyl]rapamycin Usage And Synthesis

Uses

42-O-[(1,1-Dimethylethyl)dimethylsilyl]rapamycin is an intermediate in the synthesis of 8-O-Methyl-rapamycin which is a derivative of Rapamycin (R124000), a triene macrolide antibiotic isolated from Streptomyces hygroscopicus. Name derived from the native word for Easter Island, Rapa’Nui. Used as an immunosuppressant; antirestenotic. Sirolimus (INN/USAN), also known as rapamycin, is an immunosuppressant drug used to prevent rejection in organ transplantation; it is especially useful in kidney transplants.

42-O-[(1,1-Dimethylethyl)dimethylsilyl]rapamycin(143030-02-8)Related Product Information

• Everolimus
• 2-Piperidinecarboxylic acid, 1-[[(2R,3R,6S)-6-[(2S,3E,5E,7E,9S,11R)-2,13-dimethoxy-3,9,11-trimethyl-12-oxo-3,5,7-tridecatrienyl]tetrahydro-2-hydroxy-3-methyl-2H-pyran-2-yl]oxoacetyl]-, (1S,4R,5E)-1-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-4,6-dimethyl-3,7-dioxo-5-heptenyl es...
• Everolimus EP Impurity E
• USDOYNAPNXMXOE-SPSCNLKESA-N
• Everolimus Impurity 1
• 23,27-Epoxy(7E,15E,17E,19E)-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone, 9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexam...
• Everolimus Related Compound 3
• EveroliMus-d4
• Everolimus Related Compound 2
• Rapamycin, 32-O-demethyl-
• Seco Rapamycin
• Everolimus Hydrolized Impurity
• 28-epirapamycin
• Everolimus Ring-Opening Impurity
• 2,6-di-tert-butyl-4-methylene-2,5-cyclohexadienone