2,4,5-Trifluorobenzyl alcohol Chemical Properties

Melting point:

24 °C

Boiling point:

201-204 °C (lit.)

Density 

1.4 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.472(lit.)

Flash point:

230 °F

storage temp. 

2-8°C

pka

13.17±0.10(Predicted)

form 

liquid

color 

Clear colourless

CAS DataBase Reference

144284-25-3(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38-36/38

Safety Statements 

26-36/37/39-37

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

29062990

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

2,4,5-Trifluorobenzyl alcohol Usage And Synthesis

Chemical Properties

White solid

General Description

2,4,5-Trifluorobenzyl alcohol is an aryl fluorinated building block. It is also referred to as (2,4,5-trifluorophenyl)methanol [IUPAC name].

Synthesis

GENERAL METHOD: Sodium borohydride (0.28 g, 7.5 mmol) was added to a methanol (10 mL) solution of 2,4,5-trifluorobenzaldehyde (5 mmol) cooled in an ice bath in batches over a period of 20 minutes. The reaction mixture was stirred at room temperature for 30 min. The excess sodium borohydride was quenched by adding ice water. Subsequently, the reaction mixture was concentrated and the residue was dissolved in ethyl acetate and washed twice with deionized water. The organic phase was dried with anhydrous sodium sulfate and concentrated to give 2,4,5-trifluorobenzyl alcohol in 96% yield as a colorless oil. The spectral data of the resulting compound were in agreement with standard samples from commercial sources.

References

[1] European Journal of Medicinal Chemistry, 2011, vol. 46, # 2, p. 721 - 737
[2] Organic and Biomolecular Chemistry, 2014, vol. 12, # 30, p. 5781 - 5788

2,4,5-Trifluorobenzyl alcohol(144284-25-3)Related Product Information

• 4-Fluorobenzaldehyde
• Transfluthrin
• 4-Nitrobenzyl alcohol
• Ethyl acetate
• Florfenicol
• Benzyl alcohol
• 4-Trifluoromethylbenzyl chloride
• 2-Hydroxybenzyl alcohol
• Haloperidol
• 3-Fluorobenzyl alcohol
• 4-Fluorobenzonitrile
• 2,4,5-Trifluorobenzoic acid
• 2,3,4,5,6-Pentafluorobenzyl alcohol
• Tetrafluorophthalic anhydride
• DECAFLUOROBENZHYDROL
• Tetrafluorophthalic acid
• 2,3,4,6-TETRAFLUOROBENZOIC ACID
• 2-(PENTAFLUOROPHENYL)-2-PROPANOL