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Tiron

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Tiron Basic information

Product Name:
Tiron
Synonyms:
  • 1,3-Benzenedisulfonicacid,4,5-dihydroxy-,disodiumsalt
  • 3,5-disulfocatecholdisodiumsalt
  • 3-benzenedisulfonicacid,4,5-dihydroxy-disodiumsalt
  • 4,5-dihydroxy-m-benzenedisulfonicacidisodiumsalt
  • Disodium1,2-dihydroxybenzenedisulfonate
  • Pyrocatechol-3,5-disodiumsulfonate
  • sdd
  • 4,5-DIHYDROXY-1,3-BENZENEDISULFONIC ACID, DISODIUM SALT MONOHYDRATE
CAS:
149-45-1
MF:
C6H7NaO8S2
MW:
294.22
EINECS:
205-741-5
Product Categories:
  • Aromatic Phenols
Mol File:
149-45-1.mol
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Tiron Chemical Properties

Melting point:
300 °C
Density 
2.064g/cm3 at 20℃
bulk density
465kg/m3
vapor pressure 
0Pa at 25℃
storage temp. 
Store at +15°C to +25°C.
solubility 
1350g/l
form 
Powder
color 
Off-white
PH
5.0 (10g/l, H2O, 20℃)
Water Solubility 
soluble
Sensitive 
Hygroscopic
λmax
290-291 nm (buffer pH 2.5)
Merck 
14,9465
BRN 
4629740
Stability:
Stable. Incompatible with strong oxidizing agents.
LogP
0.3 at 25℃ and pH6.5
Surface tension
72.83mN/m at 1g/L and 19.5℃
CAS DataBase Reference
149-45-1(CAS DataBase Reference)
EPA Substance Registry System
Disodium 4,5-dihydroxy-1,3-benzenedisulfonate (149-45-1)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
CZ9263000
3-9
HS Code 
29082000
Toxicity
mouse,LD50,intraperitoneal,6060mg/kg (6060mg/kg),Toxicology. Vol. 62, Pg. 203, 1990.

MSDS

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Tiron Usage And Synthesis

Chemical Properties

light tan powder

Uses

Tiron is a superoxide scavenger used in the study and examination of oxide electronics. Maintains the ability to remove or destroy magnetic moments which may occur on the surface of such materials.

Uses

In determination of trace metals.

Definition

ChEBI: Tiron is an organic molecular entity.

in vivo

Tiron (200 mg/kg, oral gavage) ameliorates oxidative stress and inflammation in a murine model of airway remodeling[2].
Tiron (300 mg/kg, i.p., daily for two weeks) alleviated apoptosis of the left ventricular cardiomyocytes in STZ-induced diabetic mice[3].

Animal Model:BALB/c mice challenged with Ovalbumin (OVA) aerosol for 8 weeks[2]
Dosage:200 mg/kg
Administration:Oral gavage.
Result:Inhibited levels of NOx, IL-13 and TGF-β1, and immunoreactivity of NF-κB.
Animal Model:STZ-induced diabetic mice[3]
Dosage:300 mg/kg
Administration:i.p., daily for two weeks.
Result:Reduced the levels of total oxidized proteins and advanced glycation end products (AGEs)-related proteins.
Inhibited cardiac myocyte apoptosis.
Decreased PKCδ localization on plasma membrane.

Purification Methods

Recrystallise it from water [Hamaguchi et al. Anal Chim Acta 9 563 1962]. Itisan indicator colour reagent for Fe, Mn, Ti and Mo ions and complexes with Al, Cd, Co, Co, Fe (III), Mn, Pd, UO22+, VO2+ and Zn. [Beilstein 11 IV 630.]

Tiron Preparation Products And Raw materials

Preparation Products

TironSupplier

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