1-(2-N-Boc-Aminoethyl)piperazine Chemical Properties

Boiling point:

357.2±27.0 °C(Predicted)

Density 

1.014±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Store in freezer, under -20°C

form 

solid

pka

12.74±0.46(Predicted)

color 

White to off-white

InChI

InChI=1S/C11H23N3O2/c1-11(2,3)16-10(15)13-6-9-14-7-4-12-5-8-14/h12H,4-9H2,1-3H3,(H,13,15)

InChIKey

VPOIPCJBJNWHSJ-UHFFFAOYSA-N

SMILES

C(OC(C)(C)C)(=O)NCCN1CCNCC1

CAS DataBase Reference

140447-78-5(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39

HazardClass 

IRRITANT

1-(2-N-Boc-Aminoethyl)piperazine Usage And Synthesis

Uses

1-[2-(Boc-amino)ethyl]piperazine is used in preparation of dihydropyrimidine derivatives as bifunctional degraders for treatment and prophylaxis of target protein-mediated diseases.

Synthesis

The general procedure for the synthesis of 1-(N-Boc-aminoethyl)piperazine from 1-CBZ-4-(BOC-aminoethyl)piperazine was as follows: hydrogen was vented into a degassed solution of benzyl 4-(2-(tert-butoxycarbonylamino)ethyl)piperazine-1-carboxylate (2.60 g, 7.16 mmol) containing 10% palladium carbon (500 mg) in methanol (50 ml), the reaction lasted for 2 hours. After completion of the reaction, the mixture was filtered through Celite. The filtrate was concentrated under vacuum to give a yellow colloidal product which was identified as tert-butyl 2-(1-piperazinyl)ethylcarbamate (1.60 g, 97% yield).

References

[1] Patent: EP1449844, 2004, A1. Location in patent: Page 34
[2] Organic and Biomolecular Chemistry, 2015, vol. 13, # 18, p. 5147 - 5157

1-(2-N-Boc-Aminoethyl)piperazine(140447-78-5)Related Product Information

• tert-Butyl carbazate
• BUTYL OLEATE
• N-Aminoethylpiperazine
• Ethyl acetate
• tert-Butyl acetate
• Diethylene glycol monobutyl ether
• 2-Ethylhexyl ferulate
• Butyl acetate
• tert-Butyl carbamate
• Cyhalofop-butyl
• Urethane
• tert-Butanol
• Tris(trimethylsilyl)phosphate
• 1,2-Dimethylhydrazine Dihydrochloride
• tert-Butyl glycinate
• tert-Butyl 4-aminobenzoate
• 2-Methylpiperazine
• 2-Butoxyethanol