Ibuprofen lysine
Ibuprofen lysine Basic information
- Product Name:
- Ibuprofen lysine
- Synonyms:
-
- IBUPROFEN LYSINE 99+
- IBUPROFEN LYSINE 99+%
- IbuprofenLysine/Lysinate
- IbuprofenLysineEdmf
- Lysinate
- Ibuprofen, L-lysine salt
- Ibuprofen-lysine complex
- l-lysine mono[4-isobutyl-alpha-methylbenzeneacetate]
- CAS:
- 57469-77-9
- MF:
- C19H32N2O4
- MW:
- 352.48
- EINECS:
- 260-751-7
- Product Categories:
-
- Inhibitors
- Mol File:
- 57469-77-9.mol
Ibuprofen lysine Chemical Properties
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- Methanol (Slightly), Water (Slightly)
- form
- Powder
- color
- White to off-white
- Water Solubility
- Soluble to 71 mg/mL (201.43 mM) in Water
- CAS DataBase Reference
- 57469-77-9(CAS DataBase Reference)
Ibuprofen lysine Usage And Synthesis
Uses
Anti-inflammatory (prostaglandin synthetase inhibitor).
Uses
Ibuprofen Lysinate is used in the treatment of hemodynamically significant patent ductus arteriosus in neonates greater than 27 week gestational age.
in vivo
Ibuprofen (300 mg/kg; p.o.; daily, for 14 days) L-lysine reduces overall tumor growth and enhances anti-tumor immune characteristics without adverse autoimmune reactions in a model of postpartum breast cancer[5].
Ibuprofen (60 mg/kg; i.h.; every second day for 15 days) L-lysine reduces the risk of neuropathy in a rat model of chronic Oxaliplatin induced peripheral neuropathy[6].
Ibuprofen (20 mg/kg; p.o.; every 12 hours, 5 doses total) L-lysine decreases muscle growth (average muscle fiber cross-sectional area) without affecting regulation of supraspinatus tendon adaptions to exercise[7].
Ibuprofen (35 mg/kg; p.o.; twice daily) L-lysine attenuates the Inflammatory response to pseudomonas aeruginosa in a rat model of chronic pulmonary infection[8].
| Animal Model: | Syngeneic (D2A1) orthotopic Balb/c mouse model of PPBC (postpartum)[5] |
| Dosage: | 300 mg/kg, daily for 14 days |
| Administration: | Fed in animal feedings (added to pulverized standard chow and mixed dry, then mixed with water, made into chow pellets and dried thoroughly) |
| Result: | Suppresed tumor growth, reduced presence of immature monocytes and increased numbers of T cells. Enhanced Th1 associated cytokines as well as promoted tumor border accumulation of T cells. |
| Animal Model: | Oxaliplatin?induced peripheral neuropathy[6] |
| Dosage: | 60 mg/kg, every second day for 15 days |
| Administration: | Subcutaneous injection |
| Result: | Lowered sensory nerve conduction velocity (SNCV). |
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