tert-Butyl (4-methylpiperidin-4-yl)carbamate Chemical Properties

Boiling point:

308 °C

Density 

1.01

Flash point:

140 °C

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

pka

12.75±0.20(Predicted)

form 

powder

color 

Gray

InChI

InChI=1S/C11H22N2O2/c1-10(2,3)15-9(14)13-11(4)5-7-12-8-6-11/h12H,5-8H2,1-4H3,(H,13,14)

InChIKey

MVUNGZMGWJXPIM-UHFFFAOYSA-N

SMILES

C(OC(C)(C)C)(=O)NC1(C)CCNCC1

Safety Information

HS Code 

2933399990

tert-Butyl (4-methylpiperidin-4-yl)carbamate Usage And Synthesis

Uses

tert-Butyl (4-methylpiperidin-4-yl)carbamate is versatile intermediates in organic synthesis, particularly in the pharmaceutical industry. They are used in the synthesis of various compounds, including natural products and potential therapeutic agents. 

Synthesis

General procedure for the synthesis of tert-butyl (4-methylpiperidin-4-yl)carbamate from (1-benzoyl-4-methylpiperidin-4-yl)carbamate: 1. tert-Butyl (1-benzoyl-4-methylpiperidin-4-yl)carbamate (318 mg, 1.0 mmol) was dissolved in ethanol (3 mL). 2. 6 N aqueous sodium hydroxide (1.0 mL, 6.0 mmol) was added to the above solution. 3. The reaction mixture was heated at reflux for 8 hours. 4. 4. Upon completion of the reaction, the mixture was concentrated under reduced pressure. 5. Ethyl acetate (30 mL) was added to the concentrated mixture. 6. The organic layer was separated and washed twice with distilled water. 7. Dry the organic layer with anhydrous magnesium sulfate. 8. Concentrate the dried organic layer under reduced pressure and dry under reduced pressure to afford the target product tert-butyl (4-methylpiperidin-4-yl)carbamate (145 mg, 0.67 mmol, 67% yield). Characterization data: Mass spectrum (EI, m/z): 214 [M]+. 1H-NMR (CDCl3) δ: 4.37 (1H, br s), 2.84-2.80 (4H, m), 1.91 (2H, dt, J = 13.3, 3.9 Hz), 1.51 (2H, td, J = 12.9, 6.2 Hz), 1.44 (9H, s), 1.34 (3H, s).

References

[1] Patent: US2012/149902, 2012, A1. Location in patent: Page/Page column 24

tert-Butyl (4-methylpiperidin-4-yl)carbamate(163271-08-7)Related Product Information

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