2-METHOXYMETHYL METHANSULFONATE Chemical Properties

Boiling point:

126 °C / 12mmHg

Density 

1.25

refractive index 

1.4300-1.4340

storage temp. 

Sealed in dry,Room Temperature

form 

clear liquid

color 

Colorless to Light yellow to Light orange

Safety Information

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39

HS Code 

2909199090

2-METHOXYMETHYL METHANSULFONATE Usage And Synthesis

Uses

2-Methoxymethyl Methansulfonate is used in the ring-opening polymerization of lactide. Also used in the synthesis of acetylcholine receptor ligands.

Synthesis

GENERAL STEPS: To a cooled solution of 2-methoxyethanol (0.8 mL) in dichloromethane (50 mL) at 0°C, methylsulfonyl chloride (1.3 mL) and triethylamine (2 mL) were added slowly and dropwise. After 5 minutes of reaction, the ice bath was removed and the reaction mixture was gradually warmed to room temperature with continuous stirring for 1 hour. Upon completion of the reaction, the reaction mixture was washed sequentially with 1.0 N NaOH solution and saturated saline, followed by drying with anhydrous magnesium sulfate and concentration under reduced pressure to give 2-methoxyethyl methane sulfonate as an oil in quantitative yield. Mass spectrum (ESI+) m/z 155.1 ([M+H]+), molecular formula C4H10O4S. 2-Methoxyethyl methane sulfonate (1.54 g) was dissolved in 2-butanone (150 mL) and cesium carbonate (6.50 g) and 3-fluoro-4-nitrophenol (1.52 g) were added. The reaction mixture was refluxed for 19 h. After cooling, it was filtered, concentrated under reduced pressure and purified by silica gel column chromatography (eluent: ethyl acetate/heptane) to give the target product in 98% yield.1H NMR (400 MHz, DMSO-d6) δ 7.95, 6.82, 6.67, 4.25, 3.92, 3.68, 3.33, 3.31. 2-Methoxy-4-(2-methoxyethoxy)-1-nitrobenzene (2.0 g) was dissolved in methanol (200 mL) and 10% Pd/C (1.0 g) and HCl (1.8 g) were added. The reaction was shaken at 40 psi hydrogen pressure for 15 minutes. After completion of the reaction, the reaction mixture was filtered and the filtrate was crystallized by ethanol/ether to give 2-methoxy-4-(2-methoxyethoxy)aniline hydrochloride in 76% yield. Mass spectrum (ESI+) m/z 198.1 ([M+H]+), molecular formula C10H15NO3. Example 156 was prepared from 2-methoxy-4-(2-methoxyethoxy)aniline hydrochloride and 2-isocyanato-5-(trifluoromethyl)-1,3,4-thiadiazole according to Method B in 50% yield. High resolution mass spectrometry (HRMS, ESI) calculated value C14H15N4O4SF3+H 393.0844 and measured value 393.0838.

References

[1] Patent: US2003/236287, 2003, A1. Location in patent: Page 38, 39
[2] Patent: US2003/236287, 2003, A1. Location in patent: Page 41
[3] Molecules, 2013, vol. 18, # 8, p. 9603 - 9622
[4] Patent: US2017/2028, 2017, A1. Location in patent: Paragraph 0162; 0163
[5] Chemistry - A European Journal, 2013, vol. 19, # 4, p. 1346 - 1356

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