N,N-Dimethylformamide dimethyl acetal Chemical Properties

Melting point:

-85°C

Boiling point:

102-103 °C/720 mmHg (lit.)

Density 

0.897 g/mL at 25 °C (lit.)

vapor pressure 

34.5hPa at 20℃

refractive index 

n20/D 1.396(lit.)

Flash point:

45 °F

storage temp. 

Store below +30°C.

solubility 

Miscible with most organic solvents.

form 

Solid

pka

5.00±0.50(Predicted)

color 

White to off-white

PH

7 (H2O)

explosive limit

1.3-17.7%(V)

Water Solubility 

hydrolysis

Sensitive 

Moisture Sensitive

BRN 

506020

Exposure limits

ACGIH: TWA 200 ppm; STEL 250 ppm (Skin)
OSHA: TWA 200 ppm(260 mg/m3)
NIOSH: IDLH 6000 ppm; TWA 200 ppm(260 mg/m3); STEL 250 ppm(325 mg/m3)

LogP

0.750 (est)

CAS DataBase Reference

4637-24-5(CAS DataBase Reference)

NIST Chemistry Reference

Methanamine, 1,1-dimethoxy-N,N-dimethyl-(4637-24-5)

EPA Substance Registry System

Methanamine, 1,1-dimethoxy-N,N-dimethyl- (4637-24-5)

Safety Information

Hazard Codes 

F,Xn,Xi

Risk Statements 

11-22-36/37/38-36/38-20-20/21/22-10-52

Safety Statements 

16-26-36/37-36/37/39-33-29-7/9

RIDADR 

UN 3271 3/PG 2

WGK Germany 

1

F 

21

Autoignition Temperature

155 °C

TSCA 

Yes

HazardClass 

3

PackingGroup 

II

HS Code 

29225000

Toxicity

LD50 orally in Rabbit: > 5000 mg/kg

MSDS

• Language:English Provider:N-Dimethoxymethyl-N,N-dimethylamine
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

N,N-Dimethylformamide dimethyl acetal Usage And Synthesis

Chemical Properties

clear colourless liquid

Uses

N,N-Dimethylformamide dimethyl acetal is used as an intermediate in the formation of pyridine derivatives, which exhibits inhibition against PI3 kinase p110alfa enzymes. It is utilized for the derivatization of primary sulfonamides and trifluoroacetic acid. It is also used in the preparation of formamidine derivatives. It is used as a reagent for n-dimethylaminomethylene and methyl esters. Further, it is used to catalyze the coupling of epoxides with carbon dioxide to prepare cyclic carbonates.

Uses

Used to catalyze the coupling of epoxides with carbon dioxide under solvent free conditions leading to cyclic carbonates.

Uses

1,1-Dimethoxy-N,N-dimethylmethanamine is used as a reagent in the formation of pyridine derivatives that exhibit inhibition against PI3 kinase p110α enzymes.

Definition

ChEBI: An acetal obtained by formal condensation of N,N-dimethylformamide with methanol. N,N-dimethylformamide dimethyl acetal is a derivatisation agent used in gas-chromatography applica ions

General Description

Esterate M (N,N-Dimethylformamide dimethyl acetal, DMFDMA) is an methylating reagent. It has been used in methyl esterification of carboxylic acid and also in one-step derivatization of amino acids into N,N-Dimethylaminomethylene methyl esters.

Flammability and Explosibility

Highly flammable

N,N-Dimethylformamide dimethyl acetal(4637-24-5)Related Product Information

• N,N-Dimethylformamide
• Dimethyl fumarate
• Acetal
• Dimethyl carbonate
• 1,1-Di-tert-butoxytrimethylamine
• Dimethyl ether
• ETHANE
• Dimethylamine
• Dimethyl sulfate
• Dimethyl sulfide
• Dimethyl sulfoxide
• N,N'-Dimethylpiperazine
• N,N'-Diemthyl-N-Methyllisonipecotamide
• N,N-Dimethylallylamine
• N,N-Dimethylacrylamide
• N,N-Dimethylglycine
• N,N-DIMETHYLFORMAMIDE DIBENZYL ACETAL
• 2-Dimethylamino-1,3-dioxolane