Basic information Safety Supplier Related

CYCLO(-ARG-GLY-ASP-D-TYR-LYS)

Basic information Safety Supplier Related

CYCLO(-ARG-GLY-ASP-D-TYR-LYS) Basic information

Product Name:
CYCLO(-ARG-GLY-ASP-D-TYR-LYS)
Synonyms:
  • CYCLO(-ARG-GLY-ASP-D-TYR-LYS)
  • CYCLO(-RGDYK)
  • cyclo (Arg-Gly-Asp-Tyr-Lys)
  • Cyclo(-Arg-Gly-Asp-D-Tyr-Lys) trifluoroacetate salt
  • Cyclo(L-arginylglycyl-L-α-aspartyl-D-tyrosyl-L-lysyl)
  • c(RGDyK),Cyclo(RGDyK)
  • 2-((2S,5R,8S,11S)-8-(4-Aminobutyl)-11-(3-guanidinopropyl)-5-(4-hydroxybenzyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaazacyclopentadecan-2-yl)acetic acid
  • Cyclo (-RGDyK) - 5 mg
CAS:
217099-14-4
MF:
C27H41N9O8
MW:
619.68
Product Categories:
  • peptide
Mol File:
217099-14-4.mol
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CYCLO(-ARG-GLY-ASP-D-TYR-LYS) Chemical Properties

Density 
1.52±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
pka
4.01±0.10(Predicted)
form 
Solid
color 
White to off-white
Sequence
Cyclo(Arg-Gly-Asp-{d-Tyr}-Lys)
InChIKey
LAROZEWEPNAWMD-OFICADHYNA-N
SMILES
C(C1C=CC(=CC=1)O)[C@H]1NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC1=O)CCCCN)=O)CCCNC(N)=N)=O)=O)CC(=O)O)=O |&1:8,11,17,20,r|
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CYCLO(-ARG-GLY-ASP-D-TYR-LYS) Usage And Synthesis

Uses

Cyclo(RGDyK) is a potent and selective αVβ3 integrin inhibitor with an IC50 of 20 nM.

IC 50

αvβ3: 20 nM (IC50)

References

[1] Haubner R, et al. Glycosylated RGD-containing peptides: tracer for tumor targeting and angiogenesis imaging with improved biokinetics. J Nucl Med. 2001 Feb;42(2):326-36. PMID:11216533

CYCLO(-ARG-GLY-ASP-D-TYR-LYS)Supplier

Shanghai HongTide Biotechnology Co.,Ltd. Gold
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Creative Peptides
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info@creative-peptides.com