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ABSINTHIN

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ABSINTHIN Basic information

Product Name:
ABSINTHIN
Synonyms:
  • ABSINTHIN
  • ABSYNTHIN
  • ABSINTHII TINCTURA
  • Absynthine
  • Absinthiin
  • Sbsinthin
  • 2H-7,13b-Ethenopentaleno[1'',2'':6,7
  • 5'',4'':6',7']dicyclohepta[1,2-b:1',2'-b']difuran-2,12(11H)-dione,3,3a,4,5,6,6a,6b,7,7a,8,9,10,10a,13a,13c,14b-hexadecahydro-6,8-dihydroxy-3,6,8,11,14,15-hexamethyl-,(3S,3aS,6S,6aR,6bS,7S,7aR,8S,10aS,11S,13aS,13bR,13cR
CAS:
1362-42-1
MF:
C30H40O6
MW:
496.64
Product Categories:
  • Miscellaneous Natural Products
Mol File:
1362-42-1.mol
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ABSINTHIN Chemical Properties

Melting point:
165-166℃ (dec.)
alpha 
D20 +107.0° (c = 1.9 in CHCl3); D20 +103.5° (c = 1.0 in CHCl3)
Boiling point:
700.6±60.0 °C(Predicted)
Density 
1.29±0.1 g/cm3 (20 ºC 760 Torr)
storage temp. 
Amber Vial, -20°C Freezer, Under inert atmosphere
solubility 
Chloroform (Slightly, Sonicated), DMSO (Slightly), Methanol (Slightly)
pka
14.66±0.70(Predicted)
form 
Solid
color 
White to Off-White
Water Solubility 
insoluble in water
Stability:
Light Sensitive, Unstable in Acidic Condition
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Safety Information

HS Code 
29329990
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ABSINTHIN Usage And Synthesis

Uses

Absinthin is an extract from the bitter liquor Absinthe, which owes its taste to substances found in the wormwood plant used in its formulation. Absinthin contributes to this bitter taste through action upon the hTAS2R14 bitter taste receptor.

Definition

ChEBI: A dimeric sesquiterpene lactone that is produced by the plant Artemisia absinthium (Wormwood). The bitter tasting constituent of Absinthe.

in vivo

Absinthin (20-80mg/kg, p.o.) relieves LPS-induced acute lung injury (reduces inflammatory cell infiltration and improves lung architecture) in mice[4].

Animal Model:LPS-induced acute lung injury in mice[4]
Dosage:20, 40, 80mg/kg
Administration:p.o.
Result:Reduced inflammatory cell infiltration and improved lung architecture.
Reduced MPO activity, infiltration of neutrophils, lung tissue wet-to-dry ratio.
Reduced the secretion of proinflammatory cytokines and chemokines (TNF-α, IL-1β, IL-6 , and MIP-1α).

ABSINTHINSupplier

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