Benzyl (2S,3R)-(+)-6-oxo-2,3-diphenyl-4-morpholinecarboxylate Chemical Properties

Melting point:

205-207 °C(lit.)

alpha 

66 º (c=5.5 in methylene chloride)

Boiling point:

583.5±50.0 °C(Predicted)

Density 

1.242±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

pka

-3.33±0.60(Predicted)

Appearance

White to off-white Solid

optical activity

[α]25/D +66°, c = 5.5 in methylene chloride

InChI

InChI=1S/C24H21NO4/c26-21-16-25(24(27)28-17-18-10-4-1-5-11-18)22(19-12-6-2-7-13-19)23(29-21)20-14-8-3-9-15-20/h1-15,22-23H,16-17H2/t22-,23+/m1/s1

InChIKey

HECRUWTZAMPQOS-PKTZIBPZSA-N

SMILES

N1(C(OCC2=CC=CC=C2)=O)CC(=O)O[C@@H](C2=CC=CC=C2)[C@H]1C1=CC=CC=C1

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-37/39

WGK Germany 

3

HS Code 

29349990

MSDS

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Benzyl (2S,3R)-(+)-6-oxo-2,3-diphenyl-4-morpholinecarboxylate Usage And Synthesis

Uses

(2S,3R)-(+)-N-Z-6-oxo-2,3-diphenylmorpholine can be used as a starting material for the synthesis of:

• α-Amino-β-silyloxy-ester, a key intermediate for the preparation of antimalarial drug quinine and its analogs.
• R, R-Formylglycine dimethylacetal, a key intermediate for the preparation of tuberculostatic compound capreomycin IB.
• 2R,5R,6S-2-(Methoxycarbonylmethyl)-5,6-diphenylmorpholine hydrochloride, a key intermediate for the preparation of an antibiotic (+)-negamycin.

Benzyl (2S,3R)-(+)-6-oxo-2,3-diphenyl-4-morpholinecarboxylate(105228-46-4)Related Product Information

• Moroxydine
• Moroxydine hydrochloride
• Biphenyl
• Benzyl isocyanate
• Benzyl benzoate
• Tridemorph
• Benzyl nicotinate
• Benzyl alcohol
• Benzyl chloride
• Dimethomorph
• Benzyl
• (+)-N-METHYLEPHEDRINE
• (S)-(-)-N-(2-HYDROXYETHYL)-ALPHA-PHENYLETHYLAMINE
• Z-SAR-OH
• 5-Phenyl-2-morpholinone
• D-(+)-Norephedrine
• BENZYL (2R,3S)-(-)-6-OXO-2,3-DIPHENYL-4-MORPHOLINECARBOXYLATE
• N-ISOPROPYL-N-METHYLGLYCINE