2-Fluoro-5-nitropyridine Chemical Properties

Melting point:

142-144 C

Boiling point:

86-87℃/7mm lit.

Density 

4,64g/cm

refractive index 

1.5250

storage temp. 

Inert atmosphere,Room Temperature

form 

Liquid

pka

-4.47±0.10(Predicted)

color 

Colorless to pale yellow

Water Solubility 

Slightly soluble in water.

Sensitive 

Moisture Sensitive

CAS DataBase Reference

456-24-6(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

20/21/22-22

Safety Statements 

36

RIDADR 

UN 1549

HS Code 

2933399990

2-Fluoro-5-nitropyridine Usage And Synthesis

Uses

It is used in the preparation of nitropyridines by nitration of pyridines with nitric acid.

Uses

2-Fluoro-5-nitropyridine can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.

Synthesis

Synthesis of 5-amino-2-fluoropyridine. A mixture of 5-nitro-2-chloropyridine (2.0 g, 12.6 mmol) and anhydrous potassium fluoride (2.2 g, 38 mmol) in a combination of sulfalone ( 6 mL) and benzene (4 mL) was stirred at RT for 20 min. The benzene was then removed by distillation. The resulting mixture was heated at 150 ??C for 12h. The mixture was cooled to RT whereupon water (60 mL) was added. The desired product was separated from the solution via steam distillation. Extraction of the distillate with diethyl ether (2 ?á 1 0 mL) followed by drying (Na2SO4) and concentration gave the compound. 5-nitro-2-fluoropyridine, water white oil (1.3 g, 73%).

2-Fluoro-5-nitropyridine(456-24-6)Related Product Information

• 2-Chloro-3-cyanopyridine
• 2,6-Lutidine
• 4-Fluoronitrobenzene
• 1-Fluoro-2-nitrobenzene
• Flupirtine
• 2-FLUORO-3-NITROPYRIDINE
• 2-Fluoro-6-methylpyridine
• 5-Bromo-2-fluoropyridine
• 5-Chloro-2-fluoropyridine
• 2-Fluoropyridine-6-carboxylic acid
• 5-Bromo-2-fluoro-4-methyl-pyridine
• 5-Chloro-2-fluoro-3-methylpyridine
• 2-CHLORO-6-FLUOROPYRIDINE
• 4-Bromo-2-fluoropyridine
• 3-Bromo-2-fluoro-5-methylpyridine
• 2-Fluoro-3-methylpyridine
• 3-Amino-2-fluoropyridine
• 3-Chloro-2-fluoro-pyridine