2-Fluoro-3-nitropyridine Chemical Properties

Melting point:

18℃

Boiling point:

110℃/10mm

Density 

1.439±0.06 g/cm3(Predicted)

refractive index 

1.5300 to 1.5340

storage temp. 

Inert atmosphere,Room Temperature

form 

Low Melting Solid

pka

-4.47±0.10(Predicted)

color 

Yellow

Water Solubility 

Slightly soluble in water.

CAS DataBase Reference

1480-87-1(CAS DataBase Reference)

Safety Information

Hazard Codes 

T,Xi,C

Risk Statements 

20/21/22-36/37/38-34

Safety Statements 

26-36/37/39-45

Hazard Note 

Toxic

HazardClass 

IRRITANT

HS Code 

2933399990

2-Fluoro-3-nitropyridine Usage And Synthesis

Uses

2-Fluoro-3-nitropyridine is used as a pharmaceutical intermediate.

Synthesis

General procedure for the synthesis of 2-fluoro-3-nitropyridine from 2-chloro-3-nitropyridine: 2-chloro-3-nitropyridine (1.00 g, 6.76 mmol) was dissolved in DMSO (33.8 ml) at room temperature, followed by addition of CsF (2.053 g, 13.51 mmol). The reaction mixture was stirred in air at 110°C for 20 hrs. After completion of the reaction, the reaction mixture was quenched with ice water and extracted with EtOAc. The organic layer was separated, washed sequentially with water and brine, dried over anhydrous Na2SO4 and concentrated under reduced pressure. Purification of the residue by column chromatography (silica gel as stationary phase and EtOAc/hexane as eluent) afforded 2-fluoro-3-nitropyridine (0.639 g, 4.86 mmol, 71.9% yield) as a colorless oil. Similarly, compounds 3B'-8B' can be prepared according to the synthesis of 2B' above.

References

[1] European Journal of Inorganic Chemistry, 2017, vol. 2017, # 2, p. 330 - 339
[2] Tetrahedron Letters, 2015, vol. 56, # 44, p. 6043 - 6046
[3] Heterocycles, 1986, vol. 24, # 11, p. 3213 - 3221
[4] Journal of Labelled Compounds and Radiopharmaceuticals, 2004, vol. 47, # 6, p. 373 - 383
[5] Tetrahedron, 2001, vol. 57, # 4, p. 739 - 750

2-Fluoro-3-nitropyridine(1480-87-1)Related Product Information

• 3-Aminopyridine
• 1-Fluoro-2-nitrobenzene
• 3-Nitropyridine
• 2-Fluoro-3-methylpyridine
• 4-Fluoronitrobenzene
• Chromium picolinate
• 6-FLUORO-3-NITROPYRIDINE,2-FLUORO-5-NITROPYRIDINE
• 2-Fluoro-3-hydroxypyridine
• 2-Fluoro-6-methylpyridine
• 5-Bromo-2-fluoropyridine
• 5-Chloro-2-fluoropyridine
• 2-Fluoropyridine-6-carboxylic acid
• 5-Bromo-2-fluoro-4-methyl-pyridine
• 5-Chloro-2-fluoro-3-methylpyridine
• 2-CHLORO-6-FLUOROPYRIDINE
• 4-Bromo-2-fluoropyridine
• 3-Bromo-2-fluoro-5-methylpyridine
• 3-Chloro-2-fluoro-pyridine