2-Fluoropyridine-6-carboxylic acid Chemical Properties

Melting point:

139-143 °C (lit.)

Boiling point:

306.3±22.0 °C(Predicted)

Density 

1.419±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

pka

3.30±0.10(Predicted)

form 

Powder or Crystalline Powder

color 

White to yellow to pale brown

CAS DataBase Reference

402-69-7(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

29333990

MSDS

• Language:English Provider:SigmaAldrich

2-Fluoropyridine-6-carboxylic acid Usage And Synthesis

Chemical Properties

White to light yellow powder

Synthesis

General procedure for the synthesis of 6-fluoro-2-pyridinecarboxylic acid from 2-fluoro-6-methylpyridine: to a solution of 2-fluoro-6-methylpyridine (2.5 g, 22.5 mmol) in water (170 ml) was added potassium permanganate (KMnO?, 2 g, 12.65 mmol) in batches and the mixture was heated to reflux. Subsequently, potassium permanganate (KMnO?, 8 g, 50.63 mmol) was added in batches and heating to reflux was continued for 3 hours. After completion of the reaction, the mixture was cooled and the precipitate was removed by filtration. The filtrate was acidified with hydrochloric acid (HCl) solution and subsequently concentrated under reduced pressure. The residue was ground with hot ethanol (EtOH), the solid was collected by filtration and the filtrate was concentrated to dryness under reduced pressure. 6-Fluoro-2-pyridinecarboxylic acid was finally obtained as a white solid (1.7 g, 53% yield); melting point 137 °C.

References

[1] Patent: WO2004/13135, 2004, A1. Location in patent: Page 46-47
[2] Patent: WO2004/13138, 2004, A2. Location in patent: Page 22
[3] Journal of Fluorine Chemistry, 2011, vol. 132, # 8, p. 541 - 547
[4] Journal of the American Chemical Society, 1949, vol. 71, p. 4152

2-Fluoropyridine-6-carboxylic acid(402-69-7)Related Product Information

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• 2-Fluoropyridine
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• Flupirtine
• 2,5-PYRIDINEDICARBOXYLIC ACID
• 2-FLUOROPYRIDINE-4-CARBOXYLIC ACID
• 2-Fluoro-6-methylpyridine
• 5-Bromo-2-fluoropyridine
• 5-Chloro-2-fluoropyridine
• 2-Fluoro-3-nitropyridine
• 5-Bromo-2-fluoro-4-methyl-pyridine
• 5-Chloro-2-fluoro-3-methylpyridine
• 4-Bromo-2-fluoropyridine