13-Oxo-9E,11E-octadecadienoic acid
13-Oxo-9E,11E-octadecadienoic acid Basic information
- Product Name:
- 13-Oxo-9E,11E-octadecadienoic acid
- Synonyms:
-
- (9E,11E)-13-Oxo-9,11-octadecadienoic acid
- 13-Oxo-trans-9,trans-11-octadecadienoic acid
- 13-Oxo-9E,11E-octadecadienoic acid
- 11E-octadecadienoic acid
- 13-Oxo-9E
- 9,11-Octadecadienoic acid, 13-oxo-, (9E,11E)-
- 13-Oxo-9E,11E-octadecadienoic acid USP/EP/BP
- 13Oxo9E,11Eoctadecadienoic acid,13 Oxo 9E,11E octadecadienoic acid
- CAS:
- 29623-29-8
- MF:
- C18H30O3
- MW:
- 294.43
- Mol File:
- 29623-29-8.mol
13-Oxo-9E,11E-octadecadienoic acid Chemical Properties
- Boiling point:
- 425.5±18.0 °C(Predicted)
- Density
- 0.966±0.06 g/cm3(Predicted)
- pka
- 4.78±0.10(Predicted)
- form
- Solid
- color
- White to off-white
13-Oxo-9E,11E-octadecadienoic acid Usage And Synthesis
Uses
13-Oxo-9E,11E-octadecadienoic acid, an isomer of 9-oxo-ODA, is a potent PPARα activator derived from tomato juice. 13-Oxo-9E,11E-octadecadienoic acid decreases plasma and hepatic triglyceride in obese diabetic mice[1].
Definition
ChEBI: 13-oxo-9E,11E-ODE is an oxooctadecadienoic acid that consists of 9E,11E-octadecadienoic acid with the oxo substituent located at position 13. It has a role as a metabolite. It is an oxo fatty acid and a 13-oxo-9,11-octadecadienoic acid.
in vivo
13-Oxo-9E,11E-octadecadienoic acid (feed; 0.02% and 0.05%; for 4 weeks) improves dyslipidemia and lowering TG content in the liver and skeletal muscle of HFD-fed KK-Ay mice[1].
| Animal Model: | Male KK-Ay mice with 4-week-old[1] |
| Dosage: | 0.02% and 0.05% |
| Administration: | Feed; for 4 weeks |
| Result: | Improved dyslipidemia and lowering TG content in the liver and skeletal muscle of HFD-fed KK-Ay mice. |
IC 50
PPARα
References
[1] Kim YI, et al. Potent PPARα activator derived from tomato juice, 13-oxo-9,11-octadecadienoic acid, decreasesplasma and hepatic triglyceride in obese diabetic mice. PLoS One. 2012;7(2):e31317. DOI:10.1371/journal.pone.0031317
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