Flusilazole Chemical Properties

Melting point:

55°

Boiling point:

393 °C [760mmHg]

Density 

1.17

vapor pressure 

3.9 x l0^-8 Pa (25 °C)

refractive index 

1.563

Flash point:

192°C

storage temp. 

0-6°C

solubility 

DMSO : 100 mg/mL (317.07 mM; Need ultrasonic)

pka

2.5 at 25℃

Water Solubility 

900 mg l^-1 (pH 1.1), 50 mg l^-1 (pH 5.7), 45 mg l^-1 (pH 7.8) at 25 °C

Merck 

13,4232

BRN 

5824097

CAS DataBase Reference

85509-19-9(CAS DataBase Reference)

EPA Substance Registry System

Flusilazole (85509-19-9)

Safety Information

Hazard Codes 

T;N,N,T

Risk Statements 

61-22-40-51/53

Safety Statements 

53-45-61

RIDADR 

UN 2588

WGK Germany 

3

RTECS 

XZ4105000

Toxicity

LD50 in male, female rats (mg/kg): 1110, 674 orally; in rabbits >2000 dermally (Fort, Moberg)

MSDS

• Language:English Provider:1-((Bis(4-fluorophenyl)methylsilyl)methyl)-1H-1,2,4-triazole

Flusilazole Usage And Synthesis

Chemical Properties

Brown-red viscous liquid

Uses

Agricultural fungicide.

Uses

Flusilazole is a silicon-containing triazole fungicide. Flusilazole is used to control fungal infections on a variety of fruit and vegetable crops

Uses

Flusilazole is a broad spectrum fungicide used to control fungal disease caused by pathogens of the Ascomycetes, Basidiomycetes and Deuteromycetes families. Flusilazole exhibits curative and preventative activities and is recommended for use in agriculture, horticulture and viticulture. Diseases controlled include eyespot, mildew, and rusts of cereals, cercospora and rust of sugar beets, leaf spots of oilseed rape, scab and mildew of pome and stone fruits, mildew and black rot of grapes and Sigatoka disease of bananas.

Definition

ChEBI: Flusilazole is an organosilicon compound that is dimethylsilane in which the hydrogens attached to the silicon are replaced by p-fluorophenyl groups and a hydrogen attached to one of the methyl groups is replaced by a 1H-1,2,4-triazol-1-yl group. It is a broad-sepctrum fungicide used to protect a variety of crops. It has a role as a xenobiotic, an environmental contaminant, an EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor and an antifungal agrochemical. It is a member of monofluorobenzenes, a member of triazoles, an organosilicon compound, a conazole fungicide and a triazole fungicide.

Metabolic pathway

Flusilazole is stable to aqueous hydrolytic and photolytic degradation. Although flusilazole is relatively stable in soil and is detected in plant and animal samples, numerous degradation products have been reported. The primary metabolic pathway involves the cleavage of the methylenesilicon or/and methylene-triazole linkage. Another primary pathway involves aryl hydroxylation followed by conjugation. The primary metabolic/degradation pathways of flusilazole in soil, plant and animals are presented in Scheme 1.

Degradation

Aqueous hydrolysis and photolysis are not sigruficant degradation pathways for flusilazole (1). Flusilazole was stable (<5% decomposition) in sterile buffers at pH 5, 7 and 9 (25 °C) for 34 days (Cadwgan, 1983). No significant degradation was observed when fusilazole was irradiated with simulated sunlight for 30 days at 300-450 nm in sterile buffer solution at pH 7 (Carter, 1986).

Flusilazole(85509-19-9)Related Product Information

• Diphenyldimethoxysilane
• Methanol
• Methyltrimethoxysilane
• Methyl salicylate
• 1,2,4-Triazole
• Silicon tetrahydride
• Phenyltrichlorosilane
• Chlorodimethylphenylsilane
• Dichlorodiphenylsilane
• Dichlorodimethylsilane
• METSULFURON METHYL
• Tribenuron methyl
• Methyl acrylate
• Methylparaben
• Phenyltriethoxysilane
• Basic Violet 1
• Kresoxim-methyl
• tert-Butyldimethylsilyl chloride