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4-Chloro-2,3-dimethylpyridine 1-oxide

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4-Chloro-2,3-dimethylpyridine 1-oxide Basic information

Product Name:
4-Chloro-2,3-dimethylpyridine 1-oxide
Synonyms:
  • 4-Chloro-2,3-dimethylpyridine-N-oxide ,98%
  • 4-Chloro-2,3-dimethy
  • 3-DiMethyl-4-chloropyridine N-oxide
  • 4-chloro-2,3-diMethyl-1$l^{5}-pyridin-1-one
  • 2,3-DiMethyl-4-chloropyridne-n-oxide
  • 4-Chloro-2,3-lutidine N-oxide, 4-Chloro-2,3-dimethylpyridinium-1-olate
  • nsc 275262
  • 2,3-DIMETHYL-4-CHLOROPYRIDINE-N-OXIDE
CAS:
59886-90-7
MF:
C7H8ClNO
MW:
157.6
EINECS:
611-910-8
Product Categories:
  • Intermediates of Rabeprazole
  • Heterocycles
  • PHARMACEUTICAL INTERMEDIATES
  • Nitric Oxide Reagents
  • Rabeprazole
  • Heterocycle-Pyridine series
  • Pyridines
  • bc0001
Mol File:
59886-90-7.mol
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4-Chloro-2,3-dimethylpyridine 1-oxide Chemical Properties

Melting point:
103-105°C
Boiling point:
338.5°C
Density 
1.19
vapor pressure 
0.346Pa at 25℃
Flash point:
158.5°C
storage temp. 
Room temperature.
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
pka
1.28±0.10(Predicted)
color 
Pale Yellow to Light Beige
LogP
0.4 at 25℃
CAS DataBase Reference
59886-90-7(CAS DataBase Reference)
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Safety Information

Safety Statements 
24/25
HS Code 
29333990
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4-Chloro-2,3-dimethylpyridine 1-oxide Usage And Synthesis

Chemical Properties

Pale Yellow Solid

Uses

An intermediate in the synthesis of rabeprazole (R070500).

Synthesis

83.0 g (0.49 mol) of 4-nitro-2,3-dimethylpyridine N-oxide and 90 g (1.54 mol) of NaCl were admixed with 1350 ml of CH3CN, 180 ml of aq. HCl (36%) and 16.6 g of benzyltributylammonium chloride, and the resulting suspension was boiled under reflux with stirring for 12 h. The resulting reaction mixture was adjusted to PH=9 using 350 ml of 20% NaOH, wherefor the existing precipitate largely dissolved. The organic phase was separated off, water was added to the aqueous phase until the precipitate had completely dissolved, and it was subsequently extracted using dichloromethane. The organic phases were combined and the solvent was removed under reduced pressure. 76.6 g (98.5%) of 4-Chloro-2,3-dimethylpyridine 1-oxide were obtained.

4-Chloro-2,3-dimethylpyridine 1-oxide Preparation Products And Raw materials

Raw materials

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