4-Chloro-2,3-dimethylpyridine 1-oxide Chemical Properties

Melting point:

103-105°C

Boiling point:

338.5°C

Density 

1.19

vapor pressure 

0.346Pa at 25℃

Flash point:

158.5°C

storage temp. 

Room temperature.

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

Solid

pka

1.28±0.10(Predicted)

color 

Pale Yellow to Light Beige

LogP

0.4 at 25℃

CAS DataBase Reference

59886-90-7(CAS DataBase Reference)

Safety Information

Safety Statements 

24/25

HS Code 

29333990

4-Chloro-2,3-dimethylpyridine 1-oxide Usage And Synthesis

Chemical Properties

Pale Yellow Solid

Uses

An intermediate in the synthesis of rabeprazole (R070500).

Synthesis

83.0 g (0.49 mol) of 4-nitro-2,3-dimethylpyridine N-oxide and 90 g (1.54 mol) of NaCl were admixed with 1350 ml of CH3CN, 180 ml of aq. HCl (36%) and 16.6 g of benzyltributylammonium chloride, and the resulting suspension was boiled under reflux with stirring for 12 h. The resulting reaction mixture was adjusted to PH=9 using 350 ml of 20% NaOH, wherefor the existing precipitate largely dissolved. The organic phase was separated off, water was added to the aqueous phase until the precipitate had completely dissolved, and it was subsequently extracted using dichloromethane. The organic phases were combined and the solvent was removed under reduced pressure. 76.6 g (98.5%) of 4-Chloro-2,3-dimethylpyridine 1-oxide were obtained.

4-Chloro-2,3-dimethylpyridine 1-oxide(59886-90-7)Related Product Information

• ETHYLENE OXIDE
• Aluminum oxide
• Zinc oxide
• 4-Chloropyridinium chloride
• 2,6-Lutidine
• Chlorodimethylphenylsilane
• tert-Butyldimethylsilyl chloride
• Clopidol
• Iron oxide
• DIMETHYLTHEXYLSILYL CHLORIDE
• NITRIC OXIDE
• Pyridine-N-oxide
• CHLORODIMETHYLVINYLSILANE
• 2,3-Lutidine
• Sodium oxide
• (Diethoxymethyl)diphenylphosphine oxide
• 4-Chloropyridine N-oxide
• 2,3-Dimethylpyridine-N-oxide