4-Chloro-2,3-dimethylpyridine 1-oxide
4-Chloro-2,3-dimethylpyridine 1-oxide Basic information
- Product Name:
- 4-Chloro-2,3-dimethylpyridine 1-oxide
- Synonyms:
-
- 4-Chloro-2,3-dimethylpyridine-N-oxide ,98%
- 4-Chloro-2,3-dimethy
- 3-DiMethyl-4-chloropyridine N-oxide
- 4-chloro-2,3-diMethyl-1$l^{5}-pyridin-1-one
- 2,3-DiMethyl-4-chloropyridne-n-oxide
- 4-Chloro-2,3-lutidine N-oxide, 4-Chloro-2,3-dimethylpyridinium-1-olate
- nsc 275262
- 2,3-DIMETHYL-4-CHLOROPYRIDINE-N-OXIDE
- CAS:
- 59886-90-7
- MF:
- C7H8ClNO
- MW:
- 157.6
- EINECS:
- 611-910-8
- Product Categories:
-
- Intermediates of Rabeprazole
- Heterocycles
- PHARMACEUTICAL INTERMEDIATES
- Nitric Oxide Reagents
- Rabeprazole
- Heterocycle-Pyridine series
- Pyridines
- bc0001
- Mol File:
- 59886-90-7.mol
4-Chloro-2,3-dimethylpyridine 1-oxide Chemical Properties
- Melting point:
- 103-105°C
- Boiling point:
- 338.5°C
- Density
- 1.19
- vapor pressure
- 0.346Pa at 25℃
- Flash point:
- 158.5°C
- storage temp.
- Room temperature.
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 1.28±0.10(Predicted)
- color
- Pale Yellow to Light Beige
- LogP
- 0.4 at 25℃
- CAS DataBase Reference
- 59886-90-7(CAS DataBase Reference)
Safety Information
- Safety Statements
- 24/25
- HS Code
- 29333990
4-Chloro-2,3-dimethylpyridine 1-oxide Usage And Synthesis
Chemical Properties
Pale Yellow Solid
Uses
An intermediate in the synthesis of rabeprazole (R070500).
Synthesis
83.0 g (0.49 mol) of 4-nitro-2,3-dimethylpyridine N-oxide and 90 g (1.54 mol) of NaCl were admixed with 1350 ml of CH3CN, 180 ml of aq. HCl (36%) and 16.6 g of benzyltributylammonium chloride, and the resulting suspension was boiled under reflux with stirring for 12 h. The resulting reaction mixture was adjusted to PH=9 using 350 ml of 20% NaOH, wherefor the existing precipitate largely dissolved. The organic phase was separated off, water was added to the aqueous phase until the precipitate had completely dissolved, and it was subsequently extracted using dichloromethane. The organic phases were combined and the solvent was removed under reduced pressure. 76.6 g (98.5%) of 4-Chloro-2,3-dimethylpyridine 1-oxide were obtained.
4-Chloro-2,3-dimethylpyridine 1-oxide Preparation Products And Raw materials
Raw materials
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4-Chloro-2,3-dimethylpyridine 1-oxide(59886-90-7)Related Product Information
- ETHYLENE OXIDE
- Aluminum oxide
- Zinc oxide
- 4-Chloropyridinium chloride
- 2,6-Lutidine
- Chlorodimethylphenylsilane
- tert-Butyldimethylsilyl chloride
- Clopidol
- Iron oxide
- DIMETHYLTHEXYLSILYL CHLORIDE
- NITRIC OXIDE
- Pyridine-N-oxide
- CHLORODIMETHYLVINYLSILANE
- 2,3-Lutidine
- Sodium oxide
- (Diethoxymethyl)diphenylphosphine oxide
- 4-Chloropyridine N-oxide
- 2,3-Dimethylpyridine-N-oxide