Buflomedil Chemical Properties

Boiling point:

454.5±45.0 °C(Predicted)

Density 

1.090±0.06 g/cm3(Predicted)

pka

10.15±0.20(Predicted)

LogP

3.131 (est)

CAS DataBase Reference

55837-25-7(CAS DataBase Reference)

NIST Chemistry Reference

Buflomedil(55837-25-7)

Safety Information

Hazard Codes 

Xn

Risk Statements 

20/21/22-36/37/38

Safety Statements 

26-36

WGK Germany 

3

RTECS 

EL9885000

HS Code 

29339990

Buflomedil Usage And Synthesis

Originator

Fonzylane,Lafon,France,1976

Uses

BAN; DCF; MI.

Definition

ChEBI: 4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-1-butanone is an aromatic ketone.

Manufacturing Process

Introduce 33.6 g (0.2 mol) of 1,3,5-trimethoxybenzene and 100 ml of chlorobenzene into a 500 ml three-neck flask with stirrer, hydrochloric acid bubbler and condenser. Stir to dissolve and add 27.7 g of 4- pyrrolidinobutyronitrile (from 4-chlorobutyronitrile and pyrrolidine). Cool to about 15°-20°C and bubble hydrochloric acid gas in for 4 hours. Cool to about 5°C and add 200 cm3 of water. Stir. Decant the aqueous layer, wash again with 150 cm3 of water. Combine the aqueous layers, drive off the traces of chlorobenzene by distilling 150 cm3 of water, and heat under reflux for one hour. Cool and render alkaline by means of 60 ml of sodium hydroxide solution of 36° Baume. Extract twice with 100 ml of ether. Wash the ether with 100 ml of water. Dry the ether over sodium sulfate and slowly run in 50 ml of 5N hydrogen chloride solution in ether, at the boil. Cool in ice. Filter, wash with ether and dry in a vacuum oven. 33.6 g of crude product are obtained. Recrystallize from 200 ml of isopropanol in the presence of 3 SA carbon black. Filter. Wash and dry in a vacuum oven.
26.9 g of a white, crystalline water-soluble powder are obtained. Yield: 39.2%. Instantaneous melting point: 192°-193°C.

Therapeutic Function

Vasodilator

Buflomedil(55837-25-7)Related Product Information

• Anisole
• 3-Methoxybenzaldehyde
• (Trifluoromethoxy)benzene
• Prostaglandin E1
• p-Anisaldehyde
• Diltiazem
• Diltiazem hydrochloride
• 4-Methoxyphenylacetic acid
• p-Anisidine
• 6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil
• 4-Methoxyphenylacetone
• 4-Methoxybenzylchloride
• BufloMedil iMpurity (o-desMethyl)
• BufloMedil Related IMpurity
• BUFLOMEDIL IMPURITY B
• Buflomedil pyridoxal phosphate
• 1-PYRROLIDINOBUTYRONITRILE(BUFLOMEDIL INTERMEDIATE)
• 2-Butanone