Pozelimab
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Pozelimab Chemical Properties
- form
- Liquid
- color
- Colorless to light yellow
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Pozelimab Usage And Synthesis
Uses
Pozelimab (REGN3918) is a fully human IgG4 anti-C5 monoclonal antibody. Pozelimab binds to C5 and C5 variants with high affinity and blocks complement-mediated hemolysis. Pozelimab can be used for the research of complement-mediated diseases[1].
in vivo
Pozelimab (15 mg/kg; s.c., once) has a prolonged pharmacokinetic (PK) with a half-life of approximately 13 days in male and female C5hu/hu mice[1].
| Animal Model: | Cynomolgus monkey[1] |
| Dosage: | 15 mg/kg |
| Administration: | Intravenous injection; 15 mg/kg, once |
| Result: | Showed a a greater exposure to monkeys compared with H4H12161P and H4H12170P. |
References
[1] Latuszek A, et al. Inhibition of complement pathway activation with Pozelimab, a fully human antibody to complement component C5. PLoS One. 2020 May 8;15(5):e0231892. DOI:10.1371/journal.pone.0231892
PozelimabSupplier
Shanghai YuanYe Biotechnology Co., Ltd.
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ShangHai Biochempartner Co.,Ltd
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Guangzhou Hongyuan Chemical Co.,Ltd
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TargetMol Chemicals Inc.
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